GCA_000974445_07408 protein (Lentzea aerocolonigenes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GCA_000974445_07408

Unannotated protein. (671 aa)

Predicted Functional Partners:

UK23_00400

0.719

UK23_00300

0.698

UK23_23750

0.678

GCA_000974445_01179

0.607

GCA_000974445_03580

0.597

GCA_000974445_02584

0.594

GCA_000974445_07275

0.589

GCA_000974445_01731

0.523

GCA_000974445_01987

0.520

GCA_000974445_01127

0.509

Your Current Organism:

Lentzea aerocolonigenes

NCBI taxonomy Id: 68170
Other names: ATCC 23870, BCRC 13661, CCRC 13661, CCRC:13661, CIP 107109, DSM 40034, IFO 13195, ISP 5034, JCM 4150, JCM 4614, L. aerocolonigenes, Lechevalieria aerocolonigenes, NBRC 13195, NRRL B-3298, NRRL ISP-5034, Nocardia aerocolonigenes, Saccharothrix aerocolonigenes, Streptomyces aerocolonigenes, strain Shinobu N 701

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GCA_000974445_01127	GCA_000974445_03580	GCA_000974445_01127	GCA_000974445_03580	Unannotated protein.	Unannotated protein.	0.601
GCA_000974445_01127	GCA_000974445_07408	GCA_000974445_01127	GCA_000974445_07408	Unannotated protein.	Unannotated protein.	0.509
GCA_000974445_01179	GCA_000974445_07408	GCA_000974445_01179	GCA_000974445_07408	Unannotated protein.	Unannotated protein.	0.607
GCA_000974445_01731	GCA_000974445_02584	GCA_000974445_01731	GCA_000974445_02584	Unannotated protein.	Unannotated protein.	0.586
GCA_000974445_01731	GCA_000974445_07408	GCA_000974445_01731	GCA_000974445_07408	Unannotated protein.	Unannotated protein.	0.523
GCA_000974445_01987	GCA_000974445_02584	GCA_000974445_01987	GCA_000974445_02584	Unannotated protein.	Unannotated protein.	0.573
GCA_000974445_01987	GCA_000974445_07408	GCA_000974445_01987	GCA_000974445_07408	Unannotated protein.	Unannotated protein.	0.520
GCA_000974445_01987	UK23_23750	GCA_000974445_01987	GCA_000974445_01217	Unannotated protein.	Unannotated protein.	0.458
GCA_000974445_02584	GCA_000974445_01731	GCA_000974445_02584	GCA_000974445_01731	Unannotated protein.	Unannotated protein.	0.586
GCA_000974445_02584	GCA_000974445_01987	GCA_000974445_02584	GCA_000974445_01987	Unannotated protein.	Unannotated protein.	0.573
GCA_000974445_02584	GCA_000974445_07408	GCA_000974445_02584	GCA_000974445_07408	Unannotated protein.	Unannotated protein.	0.594
GCA_000974445_03580	GCA_000974445_01127	GCA_000974445_03580	GCA_000974445_01127	Unannotated protein.	Unannotated protein.	0.601
GCA_000974445_03580	GCA_000974445_07275	GCA_000974445_03580	GCA_000974445_07275	Unannotated protein.	Unannotated protein.	0.682
GCA_000974445_03580	GCA_000974445_07408	GCA_000974445_03580	GCA_000974445_07408	Unannotated protein.	Unannotated protein.	0.597
GCA_000974445_03580	UK23_00300	GCA_000974445_03580	GCA_000974445_08028	Unannotated protein.	Unannotated protein.	0.623
GCA_000974445_03580	UK23_00400	GCA_000974445_03580	GCA_000974445_07989	Unannotated protein.	Unannotated protein.	0.508
GCA_000974445_07275	GCA_000974445_03580	GCA_000974445_07275	GCA_000974445_03580	Unannotated protein.	Unannotated protein.	0.682
GCA_000974445_07275	GCA_000974445_07408	GCA_000974445_07275	GCA_000974445_07408	Unannotated protein.	Unannotated protein.	0.589
GCA_000974445_07408	GCA_000974445_01127	GCA_000974445_07408	GCA_000974445_01127	Unannotated protein.	Unannotated protein.	0.509
GCA_000974445_07408	GCA_000974445_01179	GCA_000974445_07408	GCA_000974445_01179	Unannotated protein.	Unannotated protein.	0.607

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Network Stats

number of nodes:

7

number of edges:

11

average node degree:

3.14

avg. local clustering coefficient:

0.857

expected number of edges:

6

PPI enrichment p-value:

0.0474

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018345

Protein palmitoylation

5 of 35

2.41

3.53

1.32e-07

GO:0018230

peptidyl-L-cysteine S-palmitoylation

4 of 24

2.48

2.81

4.59e-06

GO:0070200

Establishment of protein localization to telomere

2 of 5

2.86

1.29

0.0046

GO:0032202

Telomere assembly

2 of 5

2.86

1.29

0.0046

GO:0061820

Telomeric D-loop disassembly

2 of 7

2.71

1.23

0.0058

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019706

Protein-cysteine S-palmitoyltransferase activity

3 of 29

2.27

1.45

0.0019

GO:0062037

D-loop DNA binding

2 of 5

2.86

1.36

0.0035

GO:0032357

Oxidized purine DNA binding

2 of 11

2.51

1.07

0.0110

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070187

Shelterin complex

2 of 7

2.71

1.0

0.0155

GO:0002178

Palmitoyltransferase complex

2 of 11

2.51

0.99

0.0155

GO:0000781

Chromosome, telomeric region

3 of 104

1.71

0.91

0.0155

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20205

peptidyl-L-cysteine S-palmitoylation, and Regulation of protein localization to phagocytic vesicle

5 of 12

2.87

5.0

4.84e-10

CL:20206

DHHC palmitoyltransferase

3 of 6

2.95

2.8

7.63e-06

CL:13601

Shelterin complex

2 of 5

2.86

1.35

0.0036

CL:20217

Mixed, incl. Golgin subfamily A member 7/ERF4 family, and Regulation of protein localization to phagocytic vesicle

2 of 6

2.78

1.31

0.0042

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-174437

Removal of the Flap Intermediate from the C-strand

3 of 18

2.48

1.9

0.00029

MAP-174414

Processive synthesis on the C-strand of the telomere

3 of 20

2.43

1.89

0.00029

MAP-174417

Telomere C-strand (Lagging Strand) Synthesis

3 of 37

2.16

1.64

0.00071

MAP-180786

Extension of Telomeres

3 of 64

1.92

1.31

0.0026

MAP-174430

Telomere C-strand synthesis initiation

2 of 14

2.41

1.1

0.0095

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0002178

Palmitoyltransferase complex

2 of 10

2.55

0.81

0.0334

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0012

Acyltransferase

3 of 69

1.89

1.3

0.0026

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01529

DHHC palmitoyltransferase

3 of 23

2.37

1.67

0.00075

PF10256

Golgin subfamily A member 7/ERF4 family

2 of 4

2.95

1.28

0.0048

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001594

Palmitoyltransferase, DHHC domain

3 of 23

2.37

1.42

0.0023

IPR019383

Golgin subfamily A member 7/ERF4

2 of 4

2.95

1.01

0.0148

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