STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GCA_000745715_02308Unannotated protein. (268 aa)    
Predicted Functional Partners:
GCA_000745715_02309
Unannotated protein.
       0.837
GCA_000745715_07389
Unannotated protein.
  
     0.759
hrcA
Unannotated protein; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
       0.745
dnaJ
Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]
       0.745
GCA_000745715_02313
Unannotated protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
 
     0.744
GCA_000745715_02312
Unannotated protein.
       0.707
GCA_000745715_02314
Unannotated protein.
       0.698
GCA_000745715_05805
Unannotated protein.
  
     0.649
GCA_000745715_02315
Unannotated protein.
       0.647
GCA_000745715_02816
Unannotated protein.
  
   
 0.643
Your Current Organism:
Streptomyces mirabilis
NCBI taxonomy Id: 68239
Other names: ATCC 27447, Actinomyces mirabilis, CBS 751.72, DSM 40553, IFO 13450, ISP 5553, JCM 4551, JCM 4791, NBRC 13450, NRRL B-2400, NRRL-ISP 5553, S. mirabilis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.