STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEU36013.1KEGG: aca:ACP_0804 transcriptional regulator, MerR family; PFAM: HTH transcriptional regulator, MerR; SMART: HTH transcriptional regulator, MerR. (126 aa)    
Predicted Functional Partners:
dnaJ-2
Heat shock protein DnaJ domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions [...]
  
 
 0.910
AEU36011.1
KEGG: pph:Ppha_1715 protein of unknown function DUF497; manually curated; PFAM: Protein of unknown function DUF497.
       0.773
AEU36012.1
KEGG: pph:Ppha_1714 hypothetical protein.
       0.773
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 0.722
sigA
RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
  
 
 0.676
AEU36008.1
KEGG: tra:Trad_1431 plasmid maintenance system killer; manually curated; PFAM: Plasmid maintenance system killer.
       0.666
AEU36009.1
SMART: Helix-turn-helix type 3; manually curated; KEGG: tra:Trad_1432 plasmid maintenance system antidote protein, XRE family; TIGRFAM: Addiction module antidote protein, HigA; PFAM: Helix-turn-helix type 3.
       0.666
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.657
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.639
AEU36246.1
RNA polymerase Rpb6; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
   
 
 0.631
Your Current Organism:
Granulicella mallensis
NCBI taxonomy Id: 682795
Other names: G. mallensis MP5ACTX8, Granulicella mallensis MP5ACTX8, Granulicella mallensis str. MP5ACTX8, Granulicella mallensis strain MP5ACTX8, Granulicella sp. MP5ACTX8
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