node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaB | purD | AciX8_0690 | AciX8_3638 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; KEGG: ftn:FTN_0420 SAICAR synthetase/phosphoribosylamine-glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | 0.628 |
guaB | purE | AciX8_0690 | AciX8_3636 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.640 |
guaB | purF | AciX8_0690 | AciX8_3642 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.788 |
guaB | purH | AciX8_0690 | AciX8_2155 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain; TIGRFAM: AICARFT/IMPCHase bienzyme; KEGG: aca:ACP_3297 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain. | 0.976 |
guaB | purK | AciX8_0690 | AciX8_3635 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.611 |
guaB | purL | AciX8_0690 | AciX8_3641 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.857 |
guaB | purM | AciX8_0690 | AciX8_3640 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: fph:Fphi_0419 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein. | 0.805 |
guaB | purM-2 | AciX8_0690 | AciX8_4398 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: aca:ACP_1372 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein. | 0.807 |
guaB | purN | AciX8_0690 | AciX8_3637 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.555 |
purD | guaB | AciX8_3638 | AciX8_0690 | Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; KEGG: ftn:FTN_0420 SAICAR synthetase/phosphoribosylamine-glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.628 |
purD | purE | AciX8_3638 | AciX8_3636 | Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; KEGG: ftn:FTN_0420 SAICAR synthetase/phosphoribosylamine-glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.999 |
purD | purF | AciX8_3638 | AciX8_3642 | Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; KEGG: ftn:FTN_0420 SAICAR synthetase/phosphoribosylamine-glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.998 |
purD | purH | AciX8_3638 | AciX8_2155 | Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; KEGG: ftn:FTN_0420 SAICAR synthetase/phosphoribosylamine-glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain; TIGRFAM: AICARFT/IMPCHase bienzyme; KEGG: aca:ACP_3297 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain. | 0.971 |
purD | purK | AciX8_3638 | AciX8_3635 | Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; KEGG: ftn:FTN_0420 SAICAR synthetase/phosphoribosylamine-glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.984 |
purD | purL | AciX8_3638 | AciX8_3641 | Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; KEGG: ftn:FTN_0420 SAICAR synthetase/phosphoribosylamine-glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.977 |
purD | purM | AciX8_3638 | AciX8_3640 | Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; KEGG: ftn:FTN_0420 SAICAR synthetase/phosphoribosylamine-glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: fph:Fphi_0419 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein. | 0.998 |
purD | purM-2 | AciX8_3638 | AciX8_4398 | Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; KEGG: ftn:FTN_0420 SAICAR synthetase/phosphoribosylamine-glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: aca:ACP_1372 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein. | 0.993 |
purD | purN | AciX8_3638 | AciX8_3637 | Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; KEGG: ftn:FTN_0420 SAICAR synthetase/phosphoribosylamine-glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
purE | guaB | AciX8_3636 | AciX8_0690 | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.640 |
purE | purD | AciX8_3636 | AciX8_3638 | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; KEGG: ftn:FTN_0420 SAICAR synthetase/phosphoribosylamine-glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | 0.999 |