STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
yajCPreprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (90 aa)    
Predicted Functional Partners:
secE
Preprotein translocase SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
   
 
 0.951
secD
Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
 
  
 0.950
secY
Preprotein translocase secY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
   
 
 0.940
ftsY
Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
    
 0.933
EFC33270.1
Signal recognition particle protein; Features C414_000040027, C414_000040028 joined to form C414_000040102 to correct 454 sequencing error (C414_000040027 identified by Glimmer3 with a raw score of 10.42, C414_000040028 identified by Glimmer3 with a raw score of 12.29). Gene function extrapolated from CJJ81176_0732 (CP000538.1) after blastn alignment (93.41 percent identity over a 895 bp alignment).
    
 0.932
secA
Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family.
     
 0.932
secF
Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
  
  
 0.909
EFC32589.1
Possible nuclease; C414_000240053 identified by Glimmer3 with a raw score of 16.34. Gene function extrapolated from C8J_1024 (CP000814.1) after blastn alignment (93.81 percent identity over a 97 bp alignment).
       0.813
EFC32590.1
Putative ATP/GTP-binding protein; C414_000240054 identified by Glimmer3 with a raw score of 14.53. Gene function extrapolated from Cj1084c (AL111168.1) after blastn alignment (91.47 percent identity over a 762 bp alignment).
       0.813
EFC32593.1
Hypothetical protein; C414_000240058 identified by Glimmer3 with a raw score of 7.24. Gene function extrapolated from JJD26997_0637 (CP000768.1) after blastn alignment (92.93 percent identity over a 396 bp alignment) - for clarity, the original product name 'conserved hypothetical protein' has been renamed.
       0.813
Your Current Organism:
Campylobacter jejuni 414
NCBI taxonomy Id: 683083
Other names: C. jejuni subsp. jejuni 414, Campylobacter jejuni subsp. jejuni 414, Campylobacter jejuni subsp. jejuni str. 414, Campylobacter jejuni subsp. jejuni strain 414
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