TCAL_00420 protein (Tigriopus californicus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TCAL_00420

Uncharacterized protein. (242 aa)

Predicted Functional Partners:

TCAL_02527

0.975

TCAL_09868

0.973

TCAL_11070

0.917

TCAL_01838

0.917

TCAL_10369

0.860

TCAL_00567

0.853

TCAL_09208

0.850

TCAL_06905

0.815

TCAL_14423

0.780

TCAL_02231

0.772

Your Current Organism:

Tigriopus californicus

NCBI taxonomy Id: 6832
Other names: T. californicus, tidepool copepod

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TCAL_00420	TCAL_00567	A0A553NDE6	A0A553PCK7	Uncharacterized protein.	Uncharacterized protein.	0.853
TCAL_00420	TCAL_01838	A0A553NDE6	A0A553NEH2	Uncharacterized protein.	Uncharacterized protein.	0.917
TCAL_00420	TCAL_02231	A0A553NDE6	A0A553P7A0	Uncharacterized protein.	GTP_cyclohydroI domain-containing protein.	0.772
TCAL_00420	TCAL_02527	A0A553NDE6	A0A553P610	Uncharacterized protein.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.975
TCAL_00420	TCAL_06905	A0A553NDE6	A0A553PL76	Uncharacterized protein.	Uncharacterized protein.	0.815
TCAL_00420	TCAL_09208	A0A553NDE6	A0A553PA16	Uncharacterized protein.	Uncharacterized protein.	0.850
TCAL_00420	TCAL_09868	A0A553NDE6	A0A553NTK8	Uncharacterized protein.	Uncharacterized protein.	0.973
TCAL_00420	TCAL_10369	A0A553NDE6	A0A553PTM9	Uncharacterized protein.	Uncharacterized protein.	0.860
TCAL_00420	TCAL_11070	A0A553NDE6	A0A553N9U4	Uncharacterized protein.	Uncharacterized protein.	0.917
TCAL_00420	TCAL_14423	A0A553NDE6	A0A553PM09	Uncharacterized protein.	SH3 domain-containing protein.	0.780
TCAL_00567	TCAL_00420	A0A553PCK7	A0A553NDE6	Uncharacterized protein.	Uncharacterized protein.	0.853
TCAL_00567	TCAL_01838	A0A553PCK7	A0A553NEH2	Uncharacterized protein.	Uncharacterized protein.	0.965
TCAL_00567	TCAL_02527	A0A553PCK7	A0A553P610	Uncharacterized protein.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.996
TCAL_00567	TCAL_06905	A0A553PCK7	A0A553PL76	Uncharacterized protein.	Uncharacterized protein.	0.999
TCAL_00567	TCAL_09208	A0A553PCK7	A0A553PA16	Uncharacterized protein.	Uncharacterized protein.	0.998
TCAL_00567	TCAL_09868	A0A553PCK7	A0A553NTK8	Uncharacterized protein.	Uncharacterized protein.	0.992
TCAL_00567	TCAL_11070	A0A553PCK7	A0A553N9U4	Uncharacterized protein.	Uncharacterized protein.	0.965
TCAL_01838	TCAL_00420	A0A553NEH2	A0A553NDE6	Uncharacterized protein.	Uncharacterized protein.	0.917
TCAL_01838	TCAL_00567	A0A553NEH2	A0A553PCK7	Uncharacterized protein.	Uncharacterized protein.	0.965
TCAL_01838	TCAL_02527	A0A553NEH2	A0A553P610	Uncharacterized protein.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.994

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

13

PPI enrichment p-value:

1.77e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006470

Protein dephosphorylation

8 of 403

2.28

6.06

4.16e-14

GO:0005983

Starch catabolic process

4 of 70

2.74

3.7

1.24e-07

GO:0046838

Phosphorylated carbohydrate dephosphorylation

4 of 85

2.65

3.61

1.60e-07

GO:0007623

Circadian rhythm

3 of 400

1.86

1.33

0.0021

GO:0006796

Phosphate-containing compound metabolic process

10 of 8535

1.05

1.27

1.60e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008138

Protein tyrosine/serine/threonine phosphatase activity

5 of 70

2.83

5.41

6.79e-11

GO:0004721

Phosphoprotein phosphatase activity

8 of 558

2.14

5.38

3.00e-13

GO:2001066

Amylopectin binding

3 of 6

3.68

4.11

3.92e-08

GO:0019203

Carbohydrate phosphatase activity

4 of 86

2.65

3.78

7.54e-08

GO:2001070

Starch binding

3 of 45

2.8

2.91

4.48e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009570

Chloroplast stroma

4 of 1452

1.42

0.99

0.0052

GO:0110165

Cellular anatomical entity

10 of 19699

0.69

0.57

0.00045

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:25640

Energy dependent regulation of mTOR by LKB1-AMPK, and CaM pathway

5 of 83

2.76

4.57

2.60e-09

CL:25743

Mixed, incl. AMP binding, and Laforin-like, dual specificity phosphatase domain

4 of 29

3.12

4.53

5.11e-09

CL:40594

Mixed, incl. Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, and bZIP transcription factor RISBZ3/4/5

3 of 13

3.34

3.45

5.66e-07

CL:25745

Mixed, incl. Laforin-like, dual specificity phosphatase domain, and AMP binding

3 of 17

3.23

3.29

1.07e-06

CL:40595

Mixed, incl. Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, and bZIP transcription factor RISBZ3/4/5

2 of 8

3.38

1.96

0.00029

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-162582

Signal Transduction

5 of 4506

1.03

0.52

0.0474

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043036

Starch grain

6 of 23

3.4

8.59

1.95e-16

GOCC:0005952

cAMP-dependent protein kinase complex

3 of 12

3.38

3.59

3.23e-07

GOCC:0009501

Amyloplast

3 of 97

2.47

2.2

7.61e-05

GOCC:0110165

Cellular anatomical entity

8 of 8339

0.96

0.92

8.72e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0904

Protein phosphatase

3 of 187

2.19

1.8

0.00034

KW-0460

Magnesium

3 of 742

1.59

0.95

0.0100

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16561

Glycogen recognition site of AMP-activated protein kinase

6 of 26

3.34

8.26

7.32e-16

PF00782

Dual specificity phosphatase, catalytic domain

6 of 33

3.24

8.08

1.32e-15

PF00069

Protein kinase domain

4 of 474

1.91

1.85

0.00015

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045204

Laforin-like, dual specificity phosphatase domain

6 of 9

3.8

9.37

1.17e-17

IPR032640

AMP-activated protein kinase, glycogen-binding domain

6 of 26

3.34

8.18

1.06e-15

IPR000340

Dual specificity phosphatase, catalytic domain

6 of 53

3.03

7.22

3.50e-14

IPR020422

Dual specificity protein phosphatase domain

6 of 57

3.0

7.17

3.95e-14

IPR000387

Tyrosine-specific protein phosphatases domain

6 of 67

2.93

6.96

7.92e-14

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00332

Serine/threonine phosphatases, family 2C, catalytic domain

3 of 40

2.86

2.81

6.91e-06

SM00100

Cyclic nucleotide-monophosphate binding domain

3 of 91

2.5

2.36

3.74e-05

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