TCAL_16562 protein (Tigriopus californicus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TCAL_16562

DNA_pol_E_B domain-containing protein. (489 aa)

Predicted Functional Partners:

TCAL_07690

0.999

TCAL_04076

0.999

TCAL_00178

0.990

TCAL_15668

0.990

TCAL_12489

0.964

TCAL_09738

0.954

TCAL_04891

0.943

TCAL_08145

0.938

TCAL_09146

0.931

TCAL_00810

0.931

Your Current Organism:

Tigriopus californicus

NCBI taxonomy Id: 6832
Other names: T. californicus, tidepool copepod

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TCAL_00178	TCAL_00810	A0A553P2K7	A0A553NDF4	Uncharacterized protein.	AAA domain-containing protein.	0.815
TCAL_00178	TCAL_04076	A0A553P2K7	A0A553PG51	Uncharacterized protein.	DNA polymerase.	0.996
TCAL_00178	TCAL_04891	A0A553P2K7	A0A553NDL6	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.908
TCAL_00178	TCAL_07690	A0A553P2K7	A0A553NDA7	Uncharacterized protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.995
TCAL_00178	TCAL_08145	A0A553P2K7	A0A553P414	Uncharacterized protein.	AAA domain-containing protein.	0.880
TCAL_00178	TCAL_09146	A0A553P2K7	A0A553N8I3	Uncharacterized protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.932
TCAL_00178	TCAL_09738	A0A553P2K7	A0A553PD78	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.867
TCAL_00178	TCAL_12489	A0A553P2K7	A0A553PC44	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.945
TCAL_00178	TCAL_16562	A0A553P2K7	A0A553NE35	Uncharacterized protein.	DNA_pol_E_B domain-containing protein.	0.990
TCAL_00810	TCAL_00178	A0A553NDF4	A0A553P2K7	AAA domain-containing protein.	Uncharacterized protein.	0.815
TCAL_00810	TCAL_04076	A0A553NDF4	A0A553PG51	AAA domain-containing protein.	DNA polymerase.	0.938
TCAL_00810	TCAL_04891	A0A553NDF4	A0A553NDL6	AAA domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.998
TCAL_00810	TCAL_07690	A0A553NDF4	A0A553NDA7	AAA domain-containing protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.910
TCAL_00810	TCAL_08145	A0A553NDF4	A0A553P414	AAA domain-containing protein.	AAA domain-containing protein.	0.999
TCAL_00810	TCAL_09146	A0A553NDF4	A0A553N8I3	AAA domain-containing protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.877
TCAL_00810	TCAL_09738	A0A553NDF4	A0A553PD78	AAA domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.778
TCAL_00810	TCAL_12489	A0A553NDF4	A0A553PC44	AAA domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.846
TCAL_00810	TCAL_15668	A0A553NDF4	A0A553PCA0	AAA domain-containing protein.	Uncharacterized protein.	0.815
TCAL_00810	TCAL_16562	A0A553NDF4	A0A553NE35	AAA domain-containing protein.	DNA_pol_E_B domain-containing protein.	0.931
TCAL_04076	TCAL_00178	A0A553PG51	A0A553P2K7	DNA polymerase.	Uncharacterized protein.	0.996

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

13

PPI enrichment p-value:

1.77e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006470

Protein dephosphorylation

8 of 403

2.28

6.06

4.16e-14

GO:0005983

Starch catabolic process

4 of 70

2.74

3.7

1.24e-07

GO:0046838

Phosphorylated carbohydrate dephosphorylation

4 of 85

2.65

3.61

1.60e-07

GO:0007623

Circadian rhythm

3 of 400

1.86

1.33

0.0021

GO:0006796

Phosphate-containing compound metabolic process

10 of 8535

1.05

1.27

1.60e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008138

Protein tyrosine/serine/threonine phosphatase activity

5 of 70

2.83

5.41

6.79e-11

GO:0004721

Phosphoprotein phosphatase activity

8 of 558

2.14

5.38

3.00e-13

GO:2001066

Amylopectin binding

3 of 6

3.68

4.11

3.92e-08

GO:0019203

Carbohydrate phosphatase activity

4 of 86

2.65

3.78

7.54e-08

GO:2001070

Starch binding

3 of 45

2.8

2.91

4.48e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009570

Chloroplast stroma

4 of 1452

1.42

0.99

0.0052

GO:0110165

Cellular anatomical entity

10 of 19699

0.69

0.57

0.00045

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:25640

Energy dependent regulation of mTOR by LKB1-AMPK, and CaM pathway

5 of 83

2.76

4.57

2.60e-09

CL:25743

Mixed, incl. AMP binding, and Laforin-like, dual specificity phosphatase domain

4 of 29

3.12

4.53

5.11e-09

CL:40594

Mixed, incl. Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, and bZIP transcription factor RISBZ3/4/5

3 of 13

3.34

3.45

5.66e-07

CL:25745

Mixed, incl. Laforin-like, dual specificity phosphatase domain, and AMP binding

3 of 17

3.23

3.29

1.07e-06

CL:40595

Mixed, incl. Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, and bZIP transcription factor RISBZ3/4/5

2 of 8

3.38

1.96

0.00029

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-162582

Signal Transduction

5 of 4506

1.03

0.52

0.0474

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043036

Starch grain

6 of 23

3.4

8.59

1.95e-16

GOCC:0005952

cAMP-dependent protein kinase complex

3 of 12

3.38

3.59

3.23e-07

GOCC:0009501

Amyloplast

3 of 97

2.47

2.2

7.61e-05

GOCC:0110165

Cellular anatomical entity

8 of 8339

0.96

0.92

8.72e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0904

Protein phosphatase

3 of 187

2.19

1.8

0.00034

KW-0460

Magnesium

3 of 742

1.59

0.95

0.0100

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16561

Glycogen recognition site of AMP-activated protein kinase

6 of 26

3.34

8.26

7.32e-16

PF00782

Dual specificity phosphatase, catalytic domain

6 of 33

3.24

8.08

1.32e-15

PF00069

Protein kinase domain

4 of 474

1.91

1.85

0.00015

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045204

Laforin-like, dual specificity phosphatase domain

6 of 9

3.8

9.37

1.17e-17

IPR032640

AMP-activated protein kinase, glycogen-binding domain

6 of 26

3.34

8.18

1.06e-15

IPR000340

Dual specificity phosphatase, catalytic domain

6 of 53

3.03

7.22

3.50e-14

IPR020422

Dual specificity protein phosphatase domain

6 of 57

3.0

7.17

3.95e-14

IPR000387

Tyrosine-specific protein phosphatases domain

6 of 67

2.93

6.96

7.92e-14

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00332

Serine/threonine phosphatases, family 2C, catalytic domain

3 of 40

2.86

2.81

6.91e-06

SM00100

Cyclic nucleotide-monophosphate binding domain

3 of 91

2.5

2.36

3.74e-05

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (20%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About