STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TCAL_07691Uncharacterized protein. (1172 aa)    
Predicted Functional Partners:
TCAL_01790
Uncharacterized protein.
   
 0.999
TCAL_05599
F-box domain-containing protein.
  
 0.941
TCAL_09226
Uncharacterized protein.
   
 0.900
TCAL_06940
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
  
 0.888
TCAL_01167
Uncharacterized protein; Belongs to the PI3/PI4-kinase family.
   
 0.880
TCAL_01841
Uncharacterized protein.
   
 0.874
TCAL_01883
ERCC4 domain-containing protein.
    
 0.865
Fen1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
  
 0.847
TCAL_07415
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
  
 0.843
TCAL_08376
DUF1767 domain-containing protein.
    
 0.833
Your Current Organism:
Tigriopus californicus
NCBI taxonomy Id: 6832
Other names: T. californicus, tidepool copepod
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.