TCAL_07009 protein (Tigriopus californicus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TCAL_07009

Uncharacterized protein. (938 aa)

Predicted Functional Partners:

TCAL_07949

0.999

TCAL_02484

0.999

TCAL_04533

0.999

TCAL_06661

0.998

TCAL_05704

0.998

TCAL_09932

0.998

TCAL_00821

0.968

TCAL_15829

0.952

TCAL_11340

0.837

TCAL_07108

0.833

Your Current Organism:

Tigriopus californicus

NCBI taxonomy Id: 6832
Other names: T. californicus, tidepool copepod

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TCAL_00821	TCAL_02484	A0A553NE84	A0A553NS45	Protein kinase domain-containing protein.	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.	0.968
TCAL_00821	TCAL_04533	A0A553NE84	A0A553PB03	Protein kinase domain-containing protein.	Uncharacterized protein.	0.966
TCAL_00821	TCAL_05704	A0A553NE84	A0A553N8P4	Protein kinase domain-containing protein.	Uncharacterized protein.	0.947
TCAL_00821	TCAL_06661	A0A553NE84	A0A553N7R7	Protein kinase domain-containing protein.	Cog4 domain-containing protein.	0.946
TCAL_00821	TCAL_07009	A0A553NE84	A0A553PDQ4	Protein kinase domain-containing protein.	Uncharacterized protein.	0.968
TCAL_00821	TCAL_07108	A0A553NE84	A0A553PCQ7	Protein kinase domain-containing protein.	Uncharacterized protein.	0.740
TCAL_00821	TCAL_07949	A0A553NE84	A0A553NG04	Protein kinase domain-containing protein.	Uncharacterized protein.	0.966
TCAL_00821	TCAL_09932	A0A553NE84	A0A553NPV3	Protein kinase domain-containing protein.	Uncharacterized protein.	0.956
TCAL_00821	TCAL_11340	A0A553NE84	A0A553P8F2	Protein kinase domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.732
TCAL_02484	TCAL_00821	A0A553NS45	A0A553NE84	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.	Protein kinase domain-containing protein.	0.968
TCAL_02484	TCAL_04533	A0A553NS45	A0A553PB03	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.	Uncharacterized protein.	0.999
TCAL_02484	TCAL_05704	A0A553NS45	A0A553N8P4	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.	Uncharacterized protein.	0.998
TCAL_02484	TCAL_06661	A0A553NS45	A0A553N7R7	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.	Cog4 domain-containing protein.	0.998
TCAL_02484	TCAL_07009	A0A553NS45	A0A553PDQ4	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.	Uncharacterized protein.	0.999
TCAL_02484	TCAL_07108	A0A553NS45	A0A553PCQ7	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.	Uncharacterized protein.	0.761
TCAL_02484	TCAL_07949	A0A553NS45	A0A553NG04	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.	Uncharacterized protein.	0.999
TCAL_02484	TCAL_09932	A0A553NS45	A0A553NPV3	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.	Uncharacterized protein.	0.999
TCAL_02484	TCAL_11340	A0A553NS45	A0A553P8F2	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.	t-SNARE coiled-coil homology domain-containing protein.	0.904
TCAL_02484	TCAL_15829	A0A553NS45	A0A553NPK3	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.	Uncharacterized protein.	0.953
TCAL_04533	TCAL_00821	A0A553PB03	A0A553NE84	Uncharacterized protein.	Protein kinase domain-containing protein.	0.966

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.962

expected number of edges:

16

PPI enrichment p-value:

3.98e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046426

Negative regulation of receptor signaling pathway via JAK-STAT

4 of 11

2.76

3.32

6.97e-07

GO:0016032

Viral process

4 of 40

2.2

2.46

1.37e-05

GO:0006271

DNA strand elongation involved in DNA replication

3 of 18

2.42

1.93

0.00024

GO:0006270

DNA replication initiation

3 of 25

2.28

1.79

0.00040

GO:0044786

Cell cycle DNA replication

3 of 27

2.24

1.78

0.00041

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031462

Cul2-RING ubiquitin ligase complex

4 of 10

2.8

3.78

9.49e-08

GO:0070449

Elongin complex

3 of 8

2.77

2.69

1.13e-05

GO:0071162

CMG complex

3 of 11

2.63

2.55

1.87e-05

GO:0031461

cullin-RING ubiquitin ligase complex

5 of 122

1.81

2.34

4.72e-06

GO:0000228

Nuclear chromosome

4 of 130

1.68

1.7

0.00015

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7345

Cul2-RING ubiquitin ligase complex, and Cul5-RING ubiquitin ligase complex

5 of 10

2.9

5.12

2.88e-10

CL:7347

VCB complex, and Elongin-C

4 of 5

3.1

4.52

5.31e-09

CL:7219

Neddylation

6 of 81

2.07

3.79

4.12e-09

CL:6178

DNA replication initiation, and Activation of the pre-replicative complex

4 of 33

2.28

2.9

1.94e-06

CL:6187

MCM N-terminal domain, and Cdc6, C-terminal

2 of 5

2.8

1.52

0.0017

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04120

Ubiquitin mediated proteolysis

5 of 212

1.57

1.85

2.14e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1234176

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

5 of 55

2.16

3.19

2.67e-07

MAP-1234174

Cellular response to hypoxia

5 of 59

2.12

3.16

2.67e-07

MAP-69239

Synthesis of DNA

4 of 131

1.68

1.54

0.00039

MAP-69306

DNA Replication

4 of 142

1.65

1.52

0.00040

MAP-8951664

Neddylation

5 of 271

1.46

0.00020

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070449

Elongin complex

2 of 7

2.65

0.95

0.0188

GOCC:0042555

MCM complex

2 of 13

2.38

0.85

0.0274

GOCC:0000151

Ubiquitin ligase complex

3 of 147

1.51

0.65

0.0476

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0347

Helicase

2 of 36

1.94

0.73

0.0431

KW-0235

DNA replication

2 of 28

2.05

0.73

0.0431

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039948

Elongin-C

2 of 2

3.2

1.12

0.0095

IPR001232

S-phase kinase-associated protein 1-like

2 of 3

3.02

1.12

0.0095

IPR041562

MCM, AAA-lid domain

2 of 7

2.65

1.01

0.0147

IPR033762

MCM OB domain

2 of 8

2.59

1.01

0.0147

IPR027925

MCM N-terminal domain

2 of 6

2.72

1.01

0.0147

(more ...)

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