STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCL53455.1DNA topoisomerase IB; Manually curated. (335 aa)    
Predicted Functional Partners:
SCL62637.1
ATP-dependent DNA helicase, Rep family; Manually curated.
    
 
 0.951
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.945
SCL52941.1
DNA gyrase subunit B.
   
 
 0.945
rnhB
RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
    
 
 0.928
SCL53466.1
ATP-dependent DNA helicase RecQ.
    
 
 0.865
SCL59159.1
ATP-dependent DNA helicase RecQ.
    
 
 0.865
SCL63709.1
ATP-dependent DNA helicase, RecQ-like.
    
 
 0.865
SCL53432.1
Histidinol-phosphate phosphatase family domain-containing protein/HAD-superfamily hydrolase, subfamily IIIA.
   
 
 0.843
SCL53435.1
Glycosyl transferases group 1.
 
 
   0.841
SCL53438.1
Glycosyltransferase involved in cell wall bisynthesis.
 
 
   0.825
Your Current Organism:
Micromonospora yangpuensis
NCBI taxonomy Id: 683228
Other names: CGMCC 4.5736, DSM 45577, M. yangpuensis, Micromonospora sp. FXJ6.011, Micromonospora yangpuensis Zhang et al. 2012, NBRC 107727, strain FXJ6.011
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.