STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
OAA18760.1PFAM: Small subunit of acetolactate synthase; ACT domain; TIGRFAM: acetolactate synthase, small subunit. (174 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.999
OAA18761.1
Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type.
 
 0.999
OAA18803.1
Threonine dehydratase; PFAM: Pyridoxal-phosphate dependent enzyme.
  
 0.977
OAA18264.1
Benzoylformate decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.
 
 0.974
OAA18997.1
Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; IMG reference gene:2639021532_SP; Belongs to the TPP enzyme family.
 
 0.973
OAA27673.1
Thiamine pyrophosphate-dependent enzyme, probable carboxylase/decarboxylase/carboligase; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain.
 
 0.972
OAA21889.1
Thiamine pyrophosphate-dependent enzyme, probable carboxylase/decarboxylase/carboligase; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; IMG reference gene:2639020655_SP.
 
 0.970
OAA22284.1
Pyruvate-ferredoxin/flavodoxin oxidoreductase; PFAM: Domain of unknown function; 4Fe-4S dicluster domain; Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric.
  
 
 0.968
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
  
 0.964
OAA18753.1
PFAM: Isocitrate/isopropylmalate dehydrogenase.
  
 0.964
Your Current Organism:
Frankia sp. EI5c
NCBI taxonomy Id: 683316
Other names: F. sp. EI5c
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.