STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFM93124.1Aminopeptidase N. (843 aa)    
Predicted Functional Partners:
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.722
SFN52634.1
Dipeptidase D.
     
 0.685
SFM86826.1
Gamma-glutamyltranspeptidase / glutathione hydrolase.
     
 0.684
SFM93146.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
       0.578
SFM78344.1
Cystathionine beta-synthase.
     
 0.573
SFM90723.1
Helix-hairpin-helix motif-containing protein.
  
     0.518
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
    0.511
SFN57768.1
Cysteine desulfurase.
  
 
  0.475
SFN02507.1
Peptidase family M1.
  
  
 
0.460
SFM72395.1
Glycosyltransferase involved in cell wall bisynthesis.
  
     0.434
Your Current Organism:
Algoriella xinjiangensis
NCBI taxonomy Id: 684065
Other names: A. xinjiangensis, Algoriella xinjiangensis Yang et al. 2016, CGMCC 1.10229, Flavobacteriaceae bacterium XJ109, JCM 16590, strain XJ109
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