arc protein (Streptomyces albulus) - STRING interaction network

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arc

Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. (588 aa)

Predicted Functional Partners:

prcA

0.996

pup

0.994

prcB

0.991

DC74_3346

0.962

DC74_2116

0.958

glpK2

0.942

pafA

0.919

DC74_4150

0.915

DC74_8098

0.810

DC74_4696

0.777

Your Current Organism:

Streptomyces albulus

NCBI taxonomy Id: 68570
Other names: ATCC 12757, BCRC 11819, CBS 711.72, CCRC 11819, CCRC:11819, DSM 40492, IFO 13410, ISP 5492, JCM 4718, KCTC 9668, NBRC 13410, NRRL B-5386, NRRL-ISP 5492, S. albulus, strain IMC S-0802

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DC74_2116	DC74_4150	DC74_2116	DC74_4150	Proteasome component.	Hypothetical protein.	0.705
DC74_2116	arc	DC74_2116	DC74_2117	Proteasome component.	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.958
DC74_2116	prcA	DC74_2116	DC74_2113	Proteasome component.	20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.	0.926
DC74_2116	prcB	DC74_2116	DC74_2114	Proteasome component.	20S proteasome subunit beta precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family.	0.926
DC74_2116	pup	DC74_2116	DC74_2115	Proteasome component.	Hypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.	0.952
DC74_3346	DC74_4696	DC74_3346	DC74_4696	Hypothetical protein.	Ankyrin-like protein.	0.781
DC74_3346	DC74_8098	DC74_3346	DC74_8098	Hypothetical protein.	Hypothetical protein.	0.781
DC74_3346	arc	DC74_3346	DC74_2117	Hypothetical protein.	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.962
DC74_3346	glpK2	DC74_3346	DC74_2130	Hypothetical protein.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.940
DC74_3346	prcA	DC74_3346	DC74_2113	Hypothetical protein.	20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.	0.863
DC74_3346	prcB	DC74_3346	DC74_2114	Hypothetical protein.	20S proteasome subunit beta precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family.	0.863
DC74_4150	DC74_2116	DC74_4150	DC74_2116	Hypothetical protein.	Proteasome component.	0.705
DC74_4150	arc	DC74_4150	DC74_2117	Hypothetical protein.	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.915
DC74_4150	pafA	DC74_4150	DC74_2110	Hypothetical protein.	Proteasome component; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine.	0.765
DC74_4150	prcA	DC74_4150	DC74_2113	Hypothetical protein.	20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.	0.976
DC74_4150	prcB	DC74_4150	DC74_2114	Hypothetical protein.	20S proteasome subunit beta precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family.	0.945
DC74_4150	pup	DC74_4150	DC74_2115	Hypothetical protein.	Hypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.	0.712
DC74_4696	DC74_3346	DC74_4696	DC74_3346	Ankyrin-like protein.	Hypothetical protein.	0.781
DC74_4696	arc	DC74_4696	DC74_2117	Ankyrin-like protein.	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.777
DC74_4696	glpK2	DC74_4696	DC74_2130	Ankyrin-like protein.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.766

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