STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
DC74_283Benzoylformate decarboxylase; Belongs to the TPP enzyme family. (532 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase small subunit.
 
 0.948
DC74_6069
Benzaldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
  
 0.921
DC74_8080
Benzoylformate decarboxylase; Belongs to the TPP enzyme family.
  
  
 
0.912
ilvC1
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.814
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.796
DC74_5641
Acetolactate synthase 1 catalytic subunit.
  
  
 
0.761
DC74_3240
Acetolactate synthase; Belongs to the TPP enzyme family.
  
  
 
0.747
DC74_7310
Glyoxylate carboligase; Belongs to the TPP enzyme family.
  
  
 
0.745
ilvD_2
Dihydroxy acid/phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.737
DC74_6549
TPP-requiring enzyme (acetolactate synthase II).
  
  
 
0.677
Your Current Organism:
Streptomyces albulus
NCBI taxonomy Id: 68570
Other names: ATCC 12757, BCRC 11819, CBS 711.72, CCRC 11819, CCRC:11819, DSM 40492, IFO 13410, ISP 5492, JCM 4718, KCTC 9668, NBRC 13410, NRRL B-5386, NRRL-ISP 5492, S. albulus, strain IMC S-0802
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