node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DC74_1872 | ilvC1 | DC74_1872 | DC74_5643 | IlvB; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.990 |
DC74_1872 | ilvD | DC74_1872 | DC74_7636 | IlvB; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.885 |
DC74_1872 | ilvD_2 | DC74_1872 | DC74_4624 | IlvB; Belongs to the TPP enzyme family. | Dihydroxy acid/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.865 |
DC74_1872 | ilvH | DC74_1872 | DC74_5642 | IlvB; Belongs to the TPP enzyme family. | Acetolactate synthase small subunit. | 0.964 |
DC74_1872 | leuA_2 | DC74_1872 | DC74_3061 | IlvB; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.887 |
DC74_1872 | leuB-2 | DC74_1872 | DC74_7621 | IlvB; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.979 |
DC74_1872 | leuD_2 | DC74_1872 | DC74_5683 | IlvB; Belongs to the TPP enzyme family. | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.649 |
DC74_3240 | ilvC1 | DC74_3240 | DC74_5643 | Acetolactate synthase; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.983 |
DC74_3240 | ilvD | DC74_3240 | DC74_7636 | Acetolactate synthase; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.804 |
DC74_3240 | ilvD_2 | DC74_3240 | DC74_4624 | Acetolactate synthase; Belongs to the TPP enzyme family. | Dihydroxy acid/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.688 |
DC74_3240 | ilvH | DC74_3240 | DC74_5642 | Acetolactate synthase; Belongs to the TPP enzyme family. | Acetolactate synthase small subunit. | 0.931 |
DC74_3240 | leuA_2 | DC74_3240 | DC74_3061 | Acetolactate synthase; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.887 |
DC74_3240 | leuB-2 | DC74_3240 | DC74_7621 | Acetolactate synthase; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.958 |
DC74_3240 | leuD_2 | DC74_3240 | DC74_5683 | Acetolactate synthase; Belongs to the TPP enzyme family. | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.464 |
DC74_5641 | ilvC1 | DC74_5641 | DC74_5643 | Acetolactate synthase 1 catalytic subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.997 |
DC74_5641 | ilvD | DC74_5641 | DC74_7636 | Acetolactate synthase 1 catalytic subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.913 |
DC74_5641 | ilvD_2 | DC74_5641 | DC74_4624 | Acetolactate synthase 1 catalytic subunit. | Dihydroxy acid/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.922 |
DC74_5641 | ilvH | DC74_5641 | DC74_5642 | Acetolactate synthase 1 catalytic subunit. | Acetolactate synthase small subunit. | 0.999 |
DC74_5641 | leuA_2 | DC74_5641 | DC74_3061 | Acetolactate synthase 1 catalytic subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.930 |
DC74_5641 | leuB-2 | DC74_5641 | DC74_7621 | Acetolactate synthase 1 catalytic subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.979 |