EIC29359.1 protein (Methylomicrobium album) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

EIC29359.1

PFAM: Transposase IS66 family. (544 aa)

Predicted Functional Partners:

EIC29358.1

0.774

EIC29357.1

0.563

EIC29915.1

0.516

EIC27892.1

0.504

EIC28480.1

0.504

EIC28773.1

0.504

EIC30086.1

0.504

EIC29316.1

0.493

EIC29350.1

0.493

EIC29455.1

0.493

Your Current Organism:

Methylomicrobium album

NCBI taxonomy Id: 686340
Other names: M. album BG8, Methylomicrobium album BG8, Methylomicrobium album str. BG8, Methylomicrobium album strain BG8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIC27892.1	EIC29359.1	Metal_0021	Metal_1579	Transposase; PFAM: IS66 Orf2 like protein.	PFAM: Transposase IS66 family.	0.504
EIC28480.1	EIC29359.1	Metal_0636	Metal_1579	Transposase; PFAM: IS66 Orf2 like protein.	PFAM: Transposase IS66 family.	0.504
EIC28773.1	EIC29359.1	Metal_0954	Metal_1579	Transposase; PFAM: IS66 Orf2 like protein.	PFAM: Transposase IS66 family.	0.504
EIC29316.1	EIC29359.1	Metal_1533	Metal_1579	Transposase; PFAM: IS66 Orf2 like protein.	PFAM: Transposase IS66 family.	0.493
EIC29350.1	EIC29359.1	Metal_1569	Metal_1579	Transposase; PFAM: IS66 Orf2 like protein.	PFAM: Transposase IS66 family.	0.493
EIC29357.1	EIC29358.1	Metal_1577	Metal_1578	Hypothetical protein.	Transposase; PFAM: IS66 Orf2 like protein.	0.773
EIC29357.1	EIC29359.1	Metal_1577	Metal_1579	Hypothetical protein.	PFAM: Transposase IS66 family.	0.563
EIC29358.1	EIC29357.1	Metal_1578	Metal_1577	Transposase; PFAM: IS66 Orf2 like protein.	Hypothetical protein.	0.773
EIC29358.1	EIC29359.1	Metal_1578	Metal_1579	Transposase; PFAM: IS66 Orf2 like protein.	PFAM: Transposase IS66 family.	0.774
EIC29359.1	EIC27892.1	Metal_1579	Metal_0021	PFAM: Transposase IS66 family.	Transposase; PFAM: IS66 Orf2 like protein.	0.504
EIC29359.1	EIC28480.1	Metal_1579	Metal_0636	PFAM: Transposase IS66 family.	Transposase; PFAM: IS66 Orf2 like protein.	0.504
EIC29359.1	EIC28773.1	Metal_1579	Metal_0954	PFAM: Transposase IS66 family.	Transposase; PFAM: IS66 Orf2 like protein.	0.504
EIC29359.1	EIC29316.1	Metal_1579	Metal_1533	PFAM: Transposase IS66 family.	Transposase; PFAM: IS66 Orf2 like protein.	0.493
EIC29359.1	EIC29350.1	Metal_1579	Metal_1569	PFAM: Transposase IS66 family.	Transposase; PFAM: IS66 Orf2 like protein.	0.493
EIC29359.1	EIC29357.1	Metal_1579	Metal_1577	PFAM: Transposase IS66 family.	Hypothetical protein.	0.563
EIC29359.1	EIC29358.1	Metal_1579	Metal_1578	PFAM: Transposase IS66 family.	Transposase; PFAM: IS66 Orf2 like protein.	0.774
EIC29359.1	EIC29455.1	Metal_1579	Metal_1685	PFAM: Transposase IS66 family.	Transposase; PFAM: IS66 Orf2 like protein.	0.493
EIC29359.1	EIC29915.1	Metal_1579	Metal_2163	PFAM: Transposase IS66 family.	Transposase; PFAM: IS66 Orf2 like protein.	0.516
EIC29359.1	EIC30086.1	Metal_1579	Metal_2358	PFAM: Transposase IS66 family.	Transposase; PFAM: IS66 Orf2 like protein.	0.504
EIC29455.1	EIC29359.1	Metal_1685	Metal_1579	Transposase; PFAM: IS66 Orf2 like protein.	PFAM: Transposase IS66 family.	0.493

page 1 of 2

Network Stats

number of nodes:

4

number of edges:

4

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.351

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 120

1.54

3.3

2.91e-14

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

11 of 59

1.84

5.27

1.10e-17

GO:0019843

rRNA binding

7 of 41

1.81

3.4

1.46e-09

GO:0003723

RNA binding

8 of 97

1.49

2.48

3.90e-09

GO:0000049

tRNA binding

4 of 26

1.76

1.8

0.00011

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

11 of 62

1.82

5.25

3.09e-18

GO:0044391

Ribosomal subunit

5 of 14

2.13

3.71

1.14e-08

GO:0015935

Small ribosomal subunit

4 of 6

2.4

3.6

9.22e-08

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:127

Ribosome

9 of 43

1.9

4.88

1.72e-14

CL:119

Ribosome

11 of 68

1.78

4.83

5.55e-17

CL:126

Ribosome

10 of 58

1.81

4.74

1.21e-15

CL:129

rRNA-binding, and Structural constituent of ribosome

7 of 34

1.89

3.92

1.02e-10

CL:182

Mixed, incl. Small ribosomal subunit, and Ribosomal protein S5 domain 2-type fold, subgroup

3 of 5

2.35

2.31

4.00e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

11 of 61

1.83

5.3

2.52e-18

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

10 of 49

1.88

5.16

5.27e-16

GOCC:0044391

Ribosomal subunit

6 of 26

1.94

3.54

4.54e-09

GOCC:0015935

Small ribosomal subunit

4 of 12

2.1

2.78

1.88e-06

GOCC:0022626

Cytosolic ribosome

4 of 22

1.83

2.2

1.35e-05

GOCC:0022627

Cytosolic small ribosomal subunit

3 of 10

2.05

1.96

0.00012

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

11 of 61

1.83

5.26

4.30e-18

KW-0699

rRNA-binding

7 of 38

1.84

3.68

2.53e-10

KW-0820

tRNA-binding

3 of 14

1.91

1.67

0.00040

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