A0A5C3LHN5 protein (Crucibulum laeve) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A5C3LHN5

Uncharacterized protein. (419 aa)

Predicted Functional Partners:

A0A5C3MAA1

0.790

A0A5C3LNM5

0.721

A0A5C3LMV6

0.697

A0A5C3M794

0.697

A0A5C3M9F1

0.693

A0A5C3M0D8

0.689

A0A5C3M695

0.689

A0A5C3M6F9

0.689

A0A5C3MG23

0.689

A0A5C3MI65

0.689

Your Current Organism:

Crucibulum laeve

NCBI taxonomy Id: 68775
Other names: C. laeve

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A5C3LHN5	A0A5C3LMV6	Uncharacterized protein.	Uncharacterized protein.	0.697
A0A5C3LHN5	A0A5C3LNM5	Uncharacterized protein.	Transcription initiation factor TFIID complex 60 kDa subunit.	0.721
A0A5C3LHN5	A0A5C3M0D8	Uncharacterized protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.689
A0A5C3LHN5	A0A5C3M695	Uncharacterized protein.	Uncharacterized protein.	0.689
A0A5C3LHN5	A0A5C3M6F9	Uncharacterized protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.689
A0A5C3LHN5	A0A5C3M794	Uncharacterized protein.	Uncharacterized protein.	0.697
A0A5C3LHN5	A0A5C3M9F1	Uncharacterized protein.	WD40-repeat-containing domain protein.	0.693
A0A5C3LHN5	A0A5C3MAA1	Uncharacterized protein.	Histone acetyltransferase subunit NuA4-domain-containing protein.	0.790
A0A5C3LHN5	A0A5C3MG23	Uncharacterized protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.689
A0A5C3LHN5	A0A5C3MI65	Uncharacterized protein.	Uncharacterized protein.	0.689
A0A5C3LMV6	A0A5C3LHN5	Uncharacterized protein.	Uncharacterized protein.	0.697
A0A5C3LMV6	A0A5C3M0D8	Uncharacterized protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.893
A0A5C3LMV6	A0A5C3M695	Uncharacterized protein.	Uncharacterized protein.	0.893
A0A5C3LMV6	A0A5C3M6F9	Uncharacterized protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.932
A0A5C3LMV6	A0A5C3MAA1	Uncharacterized protein.	Histone acetyltransferase subunit NuA4-domain-containing protein.	0.979
A0A5C3LMV6	A0A5C3MG23	Uncharacterized protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.893
A0A5C3LMV6	A0A5C3MI65	Uncharacterized protein.	Uncharacterized protein.	0.893
A0A5C3LNM5	A0A5C3LHN5	Transcription initiation factor TFIID complex 60 kDa subunit.	Uncharacterized protein.	0.721
A0A5C3M0D8	A0A5C3LHN5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Uncharacterized protein.	0.689
A0A5C3M0D8	A0A5C3LMV6	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Uncharacterized protein.	0.893

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.842

expected number of edges:

11

PPI enrichment p-value:

4.46e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016579

Protein deubiquitination

3 of 46

2.57

2.88

0.00013

GO:0006511

Ubiquitin-dependent protein catabolic process

3 of 262

1.82

1.43

0.0069

GO:0036211

Protein modification process

4 of 1352

1.23

1.0

0.0069

GO:0044260

Cellular macromolecule metabolic process

4 of 1722

1.13

0.87

0.0091

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004843

Cysteine-type deubiquitinase activity

3 of 39

2.65

3.31

3.50e-05

GO:0003682

Chromatin binding

2 of 100

2.06

1.16

0.0257

GO:0140096

Catalytic activity, acting on a protein

4 of 1397

1.22

1.04

0.0042

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031519

PcG protein complex

2 of 3

3.58

2.92

0.00018

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2292

Proteasome complex

3 of 44

2.59

3.06

7.55e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5689603

UCH proteinases

4 of 187

2.09

3.39

4.29e-06

MAP-5688426

Deubiquitination

4 of 307

1.87

2.79

1.53e-05

MAP-597592

Post-translational protein modification

4 of 1244

1.27

1.14

0.0027

MAP-392499

Metabolism of proteins

4 of 1679

1.14

0.91

0.0067

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01088

Ubiquitin carboxyl-terminal hydrolase, family 1

3 of 6

3.46

5.21

1.88e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036959

Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily

3 of 6

3.46

4.87

5.27e-07

IPR001578

Peptidase C12, ubiquitin carboxyl-terminal hydrolase

3 of 6

3.46

4.87

5.27e-07

IPR038765

Papain-like cysteine peptidase superfamily

3 of 64

2.43

2.9

0.00010

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About