A0A5C3LNL9 protein (Crucibulum laeve) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A5C3LNL9

Uncharacterized protein. (85 aa)

Predicted Functional Partners:

A0A5C3MF53

0.756

A0A5C3M7J9

0.755

A0A5C3MBG4

0.739

A0A5C3LG78

0.737

A0A5C3LG33

0.717

A0A5C3M8D6

0.712

A0A5C3MFF9

0.712

A0A5C3LIS7

0.700

A0A5C3MDP6

0.700

A0A5C3MQE4

0.700

Your Current Organism:

Crucibulum laeve

NCBI taxonomy Id: 68775
Other names: C. laeve

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A5C3LG33	A0A5C3LG78	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein; Belongs to the complex I LYR family.	0.852
A0A5C3LG33	A0A5C3LNL9	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein.	0.717
A0A5C3LG33	A0A5C3M7J9	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Ubiquitin-40S ribosomal protein S31 fusion protein.	0.766
A0A5C3LG33	A0A5C3MF53	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	SPX domain-containing protein.	0.589
A0A5C3LG78	A0A5C3LG33	Uncharacterized protein; Belongs to the complex I LYR family.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.852
A0A5C3LG78	A0A5C3LNL9	Uncharacterized protein; Belongs to the complex I LYR family.	Uncharacterized protein.	0.737
A0A5C3LG78	A0A5C3MF53	Uncharacterized protein; Belongs to the complex I LYR family.	SPX domain-containing protein.	0.512
A0A5C3LIS7	A0A5C3LNL9	Ubiquitin-60S ribosomal protein L40, variant.	Uncharacterized protein.	0.700
A0A5C3LIS7	A0A5C3M7J9	Ubiquitin-60S ribosomal protein L40, variant.	Ubiquitin-40S ribosomal protein S31 fusion protein.	0.996
A0A5C3LIS7	A0A5C3M8D6	Ubiquitin-60S ribosomal protein L40, variant.	Uncharacterized protein.	0.858
A0A5C3LIS7	A0A5C3MBG4	Ubiquitin-60S ribosomal protein L40, variant.	Ribosomal protein L21e-domain-containing protein.	0.983
A0A5C3LIS7	A0A5C3MF53	Ubiquitin-60S ribosomal protein L40, variant.	SPX domain-containing protein.	0.609
A0A5C3LIS7	A0A5C3MFF9	Ubiquitin-60S ribosomal protein L40, variant.	Mov34-domain-containing protein.	0.858
A0A5C3LNL9	A0A5C3LG33	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.717
A0A5C3LNL9	A0A5C3LG78	Uncharacterized protein.	Uncharacterized protein; Belongs to the complex I LYR family.	0.737
A0A5C3LNL9	A0A5C3LIS7	Uncharacterized protein.	Ubiquitin-60S ribosomal protein L40, variant.	0.700
A0A5C3LNL9	A0A5C3M7J9	Uncharacterized protein.	Ubiquitin-40S ribosomal protein S31 fusion protein.	0.755
A0A5C3LNL9	A0A5C3M8D6	Uncharacterized protein.	Uncharacterized protein.	0.712
A0A5C3LNL9	A0A5C3MBG4	Uncharacterized protein.	Ribosomal protein L21e-domain-containing protein.	0.739
A0A5C3LNL9	A0A5C3MDP6	Uncharacterized protein.	Uncharacterized protein.	0.700

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006357

Regulation of transcription by RNA polymerase II

8 of 408

1.35

1.97

5.32e-08

GO:0006355

Regulation of transcription, DNA-templated

10 of 600

1.28

1.93

2.60e-09

GO:0050794

Regulation of cellular process

11 of 1543

0.91

1.04

3.23e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003712

Transcription coregulator activity

7 of 67

2.08

4.38

9.55e-11

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016592

Mediator complex

8 of 18

2.71

8.48

1.42e-17

GO:0140513

Nuclear protein-containing complex

9 of 629

1.21

1.66

4.54e-08

GO:0005634

Nucleus

11 of 2417

0.72

0.68

3.91e-06

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:24339748

(2013) A downy mildew effector attenuates salicylic acid-triggered immunity in Arabidopsis by interacting with the host mediator complex.

2 of 2

3.06

1.92

0.00033

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1661

Activator

6 of 6

3.06

7.39

1.69e-14

CL:1618

RNA Polymerase II Promoter Escape, and Mediator complex

8 of 30

2.48

7.22

9.19e-16

CL:1605

DNA-directed RNA polymerase complex, and Mediator complex

10 of 140

1.91

5.23

9.19e-16

CL:1863

Mediator complex

2 of 7

2.51

1.3

0.0041

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-212436

Generic Transcription Pathway

10 of 308

1.57

3.25

9.49e-13

MAP-73857

RNA Polymerase II Transcription

10 of 454

1.4

2.49

2.15e-11

MAP-74160

Gene expression (Transcription)

10 of 631

1.26

1.94

3.68e-10

MAP-2173796

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

2 of 8

2.46

1.16

0.0074

MAP-2173793

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

2 of 13

2.24

1.01

0.0137

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990508

CKM complex

2 of 2

3.06

1.58

0.0014

GOCC:0005634

Nucleus

10 of 1424

0.9

0.94

3.64e-06

GOCC:0032991

Protein-containing complex

10 of 2455

0.67

0.56

0.00038

GOCC:0043229

Intracellular organelle

11 of 4296

0.47

0.37

0.0019

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0010

Activator

6 of 18

2.58

5.87

2.74e-12

KW-0805

Transcription regulation

6 of 133

1.71

2.72

8.78e-08

KW-0539

Nucleus

6 of 365

1.27

1.46

1.57e-05

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About