A0A5C3LRS7 protein (Crucibulum laeve) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

A0A5C3LRS7

Uncharacterized protein. (398 aa)

Predicted Functional Partners:

A0A5C3MH61

0.986

A0A5C3M755

0.985

A0A5C3M8C2

0.981

A0A5C3MEU0

0.972

A0A5C3MCF6

0.971

A0A5C3M4T0

0.968

A0A5C3LVK7

0.965

A0A5C3LWZ9

0.960

A0A5C3M7J6

0.956

A0A5C3LUP3

0.947

Your Current Organism:

Crucibulum laeve

NCBI taxonomy Id: 68775
Other names: C. laeve

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A5C3LRS7	A0A5C3LUP3	Uncharacterized protein.	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the AAA ATPase family.	0.947
A0A5C3LRS7	A0A5C3LVK7	Uncharacterized protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.965
A0A5C3LRS7	A0A5C3LWZ9	Uncharacterized protein.	UBX domain-containing protein.	0.960
A0A5C3LRS7	A0A5C3M4T0	Uncharacterized protein.	Ubiquitin-related domain-containing protein.	0.968
A0A5C3LRS7	A0A5C3M755	Uncharacterized protein.	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the AAA ATPase family.	0.985
A0A5C3LRS7	A0A5C3M7J6	Uncharacterized protein.	Ubiquitin elongating factor core-domain-containing protein.	0.956
A0A5C3LRS7	A0A5C3M8C2	Uncharacterized protein.	UBX domain-containing protein.	0.981
A0A5C3LRS7	A0A5C3MCF6	Uncharacterized protein.	OTU domain-containing protein.	0.971
A0A5C3LRS7	A0A5C3MEU0	Uncharacterized protein.	WD40-repeat-containing domain protein.	0.972
A0A5C3LRS7	A0A5C3MH61	Uncharacterized protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.986
A0A5C3LUP3	A0A5C3LRS7	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.947
A0A5C3LUP3	A0A5C3LVK7	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the AAA ATPase family.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.942
A0A5C3LUP3	A0A5C3LWZ9	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the AAA ATPase family.	UBX domain-containing protein.	0.924
A0A5C3LUP3	A0A5C3M4T0	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the AAA ATPase family.	Ubiquitin-related domain-containing protein.	0.919
A0A5C3LUP3	A0A5C3M7J6	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the AAA ATPase family.	Ubiquitin elongating factor core-domain-containing protein.	0.859
A0A5C3LUP3	A0A5C3M8C2	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the AAA ATPase family.	UBX domain-containing protein.	0.911
A0A5C3LUP3	A0A5C3MCF6	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the AAA ATPase family.	OTU domain-containing protein.	0.939
A0A5C3LUP3	A0A5C3MEU0	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the AAA ATPase family.	WD40-repeat-containing domain protein.	0.864
A0A5C3LVK7	A0A5C3LRS7	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.965
A0A5C3LVK7	A0A5C3LUP3	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the AAA ATPase family.	0.942

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

13

PPI enrichment p-value:

1.77e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006470

Protein dephosphorylation

8 of 403

2.28

6.06

4.16e-14

GO:0005983

Starch catabolic process

4 of 70

2.74

3.7

1.24e-07

GO:0046838

Phosphorylated carbohydrate dephosphorylation

4 of 85

2.65

3.61

1.60e-07

GO:0007623

Circadian rhythm

3 of 400

1.86

1.33

0.0021

GO:0006796

Phosphate-containing compound metabolic process

10 of 8535

1.05

1.27

1.60e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008138

Protein tyrosine/serine/threonine phosphatase activity

5 of 70

2.83

5.41

6.79e-11

GO:0004721

Phosphoprotein phosphatase activity

8 of 558

2.14

5.38

3.00e-13

GO:2001066

Amylopectin binding

3 of 6

3.68

4.11

3.92e-08

GO:0019203

Carbohydrate phosphatase activity

4 of 86

2.65

3.78

7.54e-08

GO:2001070

Starch binding

3 of 45

2.8

2.91

4.48e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009570

Chloroplast stroma

4 of 1452

1.42

0.99

0.0052

GO:0110165

Cellular anatomical entity

10 of 19699

0.69

0.57

0.00045

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:25640

Energy dependent regulation of mTOR by LKB1-AMPK, and CaM pathway

5 of 83

2.76

4.57

2.60e-09

CL:25743

Mixed, incl. AMP binding, and Laforin-like, dual specificity phosphatase domain

4 of 29

3.12

4.53

5.11e-09

CL:40594

Mixed, incl. Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, and bZIP transcription factor RISBZ3/4/5

3 of 13

3.34

3.45

5.66e-07

CL:25745

Mixed, incl. Laforin-like, dual specificity phosphatase domain, and AMP binding

3 of 17

3.23

3.29

1.07e-06

CL:40595

Mixed, incl. Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, and bZIP transcription factor RISBZ3/4/5

2 of 8

3.38

1.96

0.00029

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-162582

Signal Transduction

5 of 4506

1.03

0.52

0.0474

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043036

Starch grain

6 of 23

3.4

8.59

1.95e-16

GOCC:0005952

cAMP-dependent protein kinase complex

3 of 12

3.38

3.59

3.23e-07

GOCC:0009501

Amyloplast

3 of 97

2.47

2.2

7.61e-05

GOCC:0110165

Cellular anatomical entity

8 of 8339

0.96

0.92

8.72e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0904

Protein phosphatase

3 of 187

2.19

1.8

0.00034

KW-0460

Magnesium

3 of 742

1.59

0.95

0.0100

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16561

Glycogen recognition site of AMP-activated protein kinase

6 of 26

3.34

8.26

7.32e-16

PF00782

Dual specificity phosphatase, catalytic domain

6 of 33

3.24

8.08

1.32e-15

PF00069

Protein kinase domain

4 of 474

1.91

1.85

0.00015

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045204

Laforin-like, dual specificity phosphatase domain

6 of 9

3.8

9.37

1.17e-17

IPR032640

AMP-activated protein kinase, glycogen-binding domain

6 of 26

3.34

8.18

1.06e-15

IPR000340

Dual specificity phosphatase, catalytic domain

6 of 53

3.03

7.22

3.50e-14

IPR020422

Dual specificity protein phosphatase domain

6 of 57

3.0

7.17

3.95e-14

IPR000387

Tyrosine-specific protein phosphatases domain

6 of 67

2.93

6.96

7.92e-14

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00332

Serine/threonine phosphatases, family 2C, catalytic domain

3 of 40

2.86

2.81

6.91e-06

SM00100

Cyclic nucleotide-monophosphate binding domain

3 of 91

2.5

2.36

3.74e-05

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