A0A5C3MCG8 protein (Crucibulum laeve) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

A0A5C3MCG8

Endonuclease/exonuclease/phosphatase. (435 aa)

Predicted Functional Partners:

A0A5C3MJB8

0.782

A0A5C3M7J7

0.776

A0A5C3M4P4

0.753

A0A5C3M0L1

0.741

A0A5C3MFC6

0.732

A0A5C3MA90

0.720

A0A5C3MQZ9

0.716

A0A5C3MGZ3

0.709

A0A5C3LHN4

0.680

A0A5C3M8S5

0.655

Your Current Organism:

Crucibulum laeve

NCBI taxonomy Id: 68775
Other names: C. laeve

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A5C3LHN4	A0A5C3MCG8	Kinase; Belongs to the inositol phosphokinase (IPK) family.	Endonuclease/exonuclease/phosphatase.	0.680
A0A5C3M0L1	A0A5C3M7J7	PIPK domain-containing protein.	Inositol/phosphatidylinositol phosphatase.	0.956
A0A5C3M0L1	A0A5C3M8S5	PIPK domain-containing protein.	Phosphatase tensin-type domain-containing protein.	0.954
A0A5C3M0L1	A0A5C3MA90	PIPK domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.970
A0A5C3M0L1	A0A5C3MCG8	PIPK domain-containing protein.	Endonuclease/exonuclease/phosphatase.	0.741
A0A5C3M0L1	A0A5C3MFC6	PIPK domain-containing protein.	Kinase-like domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.960
A0A5C3M0L1	A0A5C3MGZ3	PIPK domain-containing protein.	Phosphatidylinositol 3 and 4-kinase-domain-containing protein.	0.948
A0A5C3M0L1	A0A5C3MQZ9	PIPK domain-containing protein.	Phosphatidylinositol phosphate phosphatase.	0.951
A0A5C3M4P4	A0A5C3M7J7	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Inositol/phosphatidylinositol phosphatase.	0.695
A0A5C3M4P4	A0A5C3M8S5	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Phosphatase tensin-type domain-containing protein.	0.963
A0A5C3M4P4	A0A5C3MCG8	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Endonuclease/exonuclease/phosphatase.	0.753
A0A5C3M4P4	A0A5C3MQZ9	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Phosphatidylinositol phosphate phosphatase.	0.802
A0A5C3M7J7	A0A5C3M0L1	Inositol/phosphatidylinositol phosphatase.	PIPK domain-containing protein.	0.956
A0A5C3M7J7	A0A5C3M4P4	Inositol/phosphatidylinositol phosphatase.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.695
A0A5C3M7J7	A0A5C3M8S5	Inositol/phosphatidylinositol phosphatase.	Phosphatase tensin-type domain-containing protein.	0.945
A0A5C3M7J7	A0A5C3MA90	Inositol/phosphatidylinositol phosphatase.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.981
A0A5C3M7J7	A0A5C3MCG8	Inositol/phosphatidylinositol phosphatase.	Endonuclease/exonuclease/phosphatase.	0.776
A0A5C3M7J7	A0A5C3MFC6	Inositol/phosphatidylinositol phosphatase.	Kinase-like domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.958
A0A5C3M7J7	A0A5C3MGZ3	Inositol/phosphatidylinositol phosphatase.	Phosphatidylinositol 3 and 4-kinase-domain-containing protein.	0.948
A0A5C3M7J7	A0A5C3MQZ9	Inositol/phosphatidylinositol phosphatase.	Phosphatidylinositol phosphate phosphatase.	0.961

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.739

expected number of edges:

20

PPI enrichment p-value:

0.0104

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

6 of 12

1.94

3.13

7.92e-08

GO:0006091

Generation of precursor metabolites and energy

7 of 27

1.66

2.62

7.92e-08

GO:0006006

Glucose metabolic process

4 of 8

1.94

2.31

1.28e-05

GO:0006094

Gluconeogenesis

3 of 5

2.02

1.82

0.00024

GO:0016310

Phosphorylation

8 of 109

1.11

1.32

1.07e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000015

Phosphopyruvate hydratase complex

2 of 2

2.25

0.95

0.0177

GO:0009986

Cell surface

2 of 3

2.07

0.93

0.0177

GO:0009274

Peptidoglycan-based cell wall

2 of 5

1.85

0.87

0.0204

GO:0005576

Extracellular region

2 of 13

1.43

0.63

0.0498

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25152889

(2014) Metabolic Engineering of Escherichia coli for Production of Mixed-Acid Fermentation End Products.

5 of 12

1.87

2.43

3.85e-06

PMID:32432104

(2020) Recent Advances in Metabolically Engineered Microorganisms for the Production of Aromatic Chemicals Derived From Aromatic Amino Acids.

3 of 8

1.82

1.22

0.0035

PMID:35638860

(2022) Metatranscriptomics Unravel Composition, Drivers, and Functions of the Active Microorganisms in Light-Flavor Liquor Fermentation.

3 of 11

1.68

1.11

0.0051

PMID:38298832

(2024) Staphylococcus aureus biofilm: Formulation, regulatory, and emerging natural products-derived therapeutics.

2 of 2

2.25

1.0

0.0139

PMID:37969339

(2023) Complete genome sequence of Pediococcus acidilactici CACC 537 isolated from canine.

2 of 3

2.07

0.92

0.0185

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2073

Glycolysis, and Aldehyde-lyase activity

8 of 15

1.97

4.48

7.08e-12

CL:2067

Carbon metabolism, and Alcohol dehydrogenase-like, N-terminal

9 of 63

1.4

2.34

6.10e-10

CL:2075

Glycolysis, and Aldehyde-lyase activity

4 of 8

1.94

2.32

1.20e-05

CL:982

Glycerate kinase, and Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

2 of 5

1.85

0.84

0.0245

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

paci00260

Glycine, serine and threonine metabolism

4 of 7

2.0

2.68

1.97e-06

paci00680

Methane metabolism

5 of 15

1.77

2.64

3.74e-07

paci00010

Glycolysis / Gluconeogenesis

7 of 35

1.55

2.57

8.86e-09

paci01200

Carbon metabolism

9 of 59

1.43

2.53

6.95e-11

paci01230

Biosynthesis of amino acids

7 of 37

1.52

2.5

1.00e-08

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

6 of 9

2.07

3.77

4.78e-09

KW-0312

Gluconeogenesis

3 of 4

2.12

1.76

0.00037

KW-0964

Secreted

2 of 3

2.07

0.97

0.0152

KW-0456

Lyase

3 of 25

1.32

0.78

0.0161

KW-0670

Pyruvate

2 of 9

1.59

0.66

0.0491

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01193

Enolase, N-terminal domain

2 of 2

2.25

0.96

0.0166

SM01192

Enolase, C-terminal TIM barrel domain

2 of 2

2.25

0.96

0.0166

SM00855

Phosphoglycerate mutase family

2 of 6

1.77

0.82

0.0256

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