node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OCH19631.1 | OCH21537.1 | A6E04_16540 | A6E04_06620 | Glycerophosphoryl diester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycerophosphodiester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.737 |
OCH19631.1 | OCH23305.1 | A6E04_16540 | A6E04_05205 | Glycerophosphoryl diester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Transcriptional initiation protein Tat; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.568 |
OCH20274.1 | OCH23305.1 | A6E04_00930 | A6E04_05205 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Transcriptional initiation protein Tat; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.686 |
OCH20274.1 | guaA | A6E04_00930 | A6E04_14070 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.930 |
OCH20274.1 | guaB | A6E04_00930 | A6E04_14075 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.856 |
OCH20274.1 | guaC | A6E04_00930 | A6E04_15700 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.761 |
OCH20274.1 | purA | A6E04_00930 | A6E04_06335 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.731 |
OCH20274.1 | surE | A6E04_00930 | A6E04_14700 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.677 |
OCH20376.1 | OCH23305.1 | A6E04_01475 | A6E04_05205 | Damage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CinA family. | Transcriptional initiation protein Tat; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.686 |
OCH20376.1 | surE | A6E04_01475 | A6E04_14700 | Damage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CinA family. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.731 |
OCH21537.1 | OCH19631.1 | A6E04_06620 | A6E04_16540 | Glycerophosphodiester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycerophosphoryl diester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.737 |
OCH21537.1 | OCH23305.1 | A6E04_06620 | A6E04_05205 | Glycerophosphodiester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Transcriptional initiation protein Tat; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.688 |
OCH23305.1 | OCH19631.1 | A6E04_05205 | A6E04_16540 | Transcriptional initiation protein Tat; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycerophosphoryl diester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.568 |
OCH23305.1 | OCH20274.1 | A6E04_05205 | A6E04_00930 | Transcriptional initiation protein Tat; Derived by automated computational analysis using gene prediction method: Protein Homology. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.686 |
OCH23305.1 | OCH20376.1 | A6E04_05205 | A6E04_01475 | Transcriptional initiation protein Tat; Derived by automated computational analysis using gene prediction method: Protein Homology. | Damage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CinA family. | 0.686 |
OCH23305.1 | OCH21537.1 | A6E04_05205 | A6E04_06620 | Transcriptional initiation protein Tat; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycerophosphodiester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.688 |
OCH23305.1 | cpdA | A6E04_05205 | A6E04_05905 | Transcriptional initiation protein Tat; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3',5'-cyclic-AMP phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.501 |
OCH23305.1 | guaA | A6E04_05205 | A6E04_14070 | Transcriptional initiation protein Tat; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.777 |
OCH23305.1 | guaB | A6E04_05205 | A6E04_14075 | Transcriptional initiation protein Tat; Derived by automated computational analysis using gene prediction method: Protein Homology. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.694 |
OCH23305.1 | guaC | A6E04_05205 | A6E04_15700 | Transcriptional initiation protein Tat; Derived by automated computational analysis using gene prediction method: Protein Homology. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.554 |