| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EGN55698.1 | EGN56085.1 | Premu_0212 | Premu_0609 | COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146; KEGG: pru:PRU_2071 putative glutamine synthetase; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp; SPTR: Glutamine synthetase, catalytic domain protein; IMG reference gene:2503874221; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain. | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.468 |
| EGN55698.1 | EGN56504.1 | Premu_0212 | Premu_1064 | COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146; KEGG: pru:PRU_2071 putative glutamine synthetase; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp; SPTR: Glutamine synthetase, catalytic domain protein; IMG reference gene:2503874221; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain. | Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: pru:PRU_1960 glutamate synthase large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase, large subunit; IMG reference gene:2503875102; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | 0.954 |
| EGN55698.1 | EGN57299.1 | Premu_0212 | Premu_1896 | COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146; KEGG: pru:PRU_2071 putative glutamine synthetase; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp; SPTR: Glutamine synthetase, catalytic domain protein; IMG reference gene:2503874221; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain. | COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR006004:IPR001433:IPR019480:IPR013027; KEGG: pmz:HMPREF0659_A6962 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Oxidoreductase FAD/NAD(P)-binding; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; PRIAM: Glutamate synthase (NADPH); SPTR: Glutamate synthase, small subunit; TIGRFAM: Glutamate synthase (NADPH), homotetrameric; IMG reference gene:2503875949; PFAM: Pyridine nucleotide-d [...] | 0.763 |
| EGN55698.1 | EGN57625.1 | Premu_0212 | Premu_2238 | COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146; KEGG: pru:PRU_2071 putative glutamine synthetase; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp; SPTR: Glutamine synthetase, catalytic domain protein; IMG reference gene:2503874221; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain. | L-glutamine synthetase; COGs: COG3968 Uncharacterized protein related to glutamine synthetase; InterPro IPR008146; KEGG: pmz:HMPREF0659_A5221 glutamate--ammonia ligase, catalytic domain protein; PFAM: Glutamine synthetase, catalytic domain; SPTR: Type III glutamine synthetase; IMG reference gene:2503876304; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase type III N terminal. | 0.771 |
| EGN55698.1 | murI | Premu_0212 | Premu_2467 | COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146; KEGG: pru:PRU_2071 putative glutamine synthetase; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp; SPTR: Glutamine synthetase, catalytic domain protein; IMG reference gene:2503874221; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.775 |
| EGN56085.1 | EGN55698.1 | Premu_0609 | Premu_0212 | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146; KEGG: pru:PRU_2071 putative glutamine synthetase; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp; SPTR: Glutamine synthetase, catalytic domain protein; IMG reference gene:2503874221; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain. | 0.468 |
| EGN56085.1 | EGN56504.1 | Premu_0609 | Premu_1064 | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: pru:PRU_1960 glutamate synthase large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase, large subunit; IMG reference gene:2503875102; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | 0.532 |
| EGN56085.1 | murD | Premu_0609 | Premu_0419 | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.538 |
| EGN56085.1 | murI | Premu_0609 | Premu_2467 | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.904 |
| EGN56466.1 | EGN56504.1 | Premu_1024 | Premu_1064 | COGs: COG0686 Alanine dehydrogenase; InterPro IPR008141:IPR007886:IPR007698; KEGG: pru:PRU_2067 alanine dehydrogenase; PFAM: Alanine dehydrogenase/PNT, C-terminal; Alanine dehydrogenase/PNT, N-terminal; PRIAM: Alanine dehydrogenase; SPTR: Alanine dehydrogenase; TIGRFAM: Alanine dehydrogenase/pyridine nucleotide transhydrogenase; IMG reference gene:2503875062; PFAM: Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase/PNT, N-terminal domain; TIGRFAM: alanine dehydrogenase; Belongs to the AlaDH/PNT family. | Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: pru:PRU_1960 glutamate synthase large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase, large subunit; IMG reference gene:2503875102; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | 0.545 |
| EGN56466.1 | murI | Premu_1024 | Premu_2467 | COGs: COG0686 Alanine dehydrogenase; InterPro IPR008141:IPR007886:IPR007698; KEGG: pru:PRU_2067 alanine dehydrogenase; PFAM: Alanine dehydrogenase/PNT, C-terminal; Alanine dehydrogenase/PNT, N-terminal; PRIAM: Alanine dehydrogenase; SPTR: Alanine dehydrogenase; TIGRFAM: Alanine dehydrogenase/pyridine nucleotide transhydrogenase; IMG reference gene:2503875062; PFAM: Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase/PNT, N-terminal domain; TIGRFAM: alanine dehydrogenase; Belongs to the AlaDH/PNT family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.655 |
| EGN56504.1 | EGN55698.1 | Premu_1064 | Premu_0212 | Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: pru:PRU_1960 glutamate synthase large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase, large subunit; IMG reference gene:2503875102; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146; KEGG: pru:PRU_2071 putative glutamine synthetase; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp; SPTR: Glutamine synthetase, catalytic domain protein; IMG reference gene:2503874221; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain. | 0.954 |
| EGN56504.1 | EGN56085.1 | Premu_1064 | Premu_0609 | Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: pru:PRU_1960 glutamate synthase large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase, large subunit; IMG reference gene:2503875102; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.532 |
| EGN56504.1 | EGN56466.1 | Premu_1064 | Premu_1024 | Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: pru:PRU_1960 glutamate synthase large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase, large subunit; IMG reference gene:2503875102; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | COGs: COG0686 Alanine dehydrogenase; InterPro IPR008141:IPR007886:IPR007698; KEGG: pru:PRU_2067 alanine dehydrogenase; PFAM: Alanine dehydrogenase/PNT, C-terminal; Alanine dehydrogenase/PNT, N-terminal; PRIAM: Alanine dehydrogenase; SPTR: Alanine dehydrogenase; TIGRFAM: Alanine dehydrogenase/pyridine nucleotide transhydrogenase; IMG reference gene:2503875062; PFAM: Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase/PNT, N-terminal domain; TIGRFAM: alanine dehydrogenase; Belongs to the AlaDH/PNT family. | 0.545 |
| EGN56504.1 | EGN57299.1 | Premu_1064 | Premu_1896 | Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: pru:PRU_1960 glutamate synthase large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase, large subunit; IMG reference gene:2503875102; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR006004:IPR001433:IPR019480:IPR013027; KEGG: pmz:HMPREF0659_A6962 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Oxidoreductase FAD/NAD(P)-binding; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; PRIAM: Glutamate synthase (NADPH); SPTR: Glutamate synthase, small subunit; TIGRFAM: Glutamate synthase (NADPH), homotetrameric; IMG reference gene:2503875949; PFAM: Pyridine nucleotide-d [...] | 0.999 |
| EGN56504.1 | EGN57625.1 | Premu_1064 | Premu_2238 | Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: pru:PRU_1960 glutamate synthase large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase, large subunit; IMG reference gene:2503875102; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | L-glutamine synthetase; COGs: COG3968 Uncharacterized protein related to glutamine synthetase; InterPro IPR008146; KEGG: pmz:HMPREF0659_A5221 glutamate--ammonia ligase, catalytic domain protein; PFAM: Glutamine synthetase, catalytic domain; SPTR: Type III glutamine synthetase; IMG reference gene:2503876304; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase type III N terminal. | 0.946 |
| EGN56504.1 | murI | Premu_1064 | Premu_2467 | Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: pru:PRU_1960 glutamate synthase large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase, large subunit; IMG reference gene:2503875102; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.925 |
| EGN57299.1 | EGN55698.1 | Premu_1896 | Premu_0212 | COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR006004:IPR001433:IPR019480:IPR013027; KEGG: pmz:HMPREF0659_A6962 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Oxidoreductase FAD/NAD(P)-binding; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; PRIAM: Glutamate synthase (NADPH); SPTR: Glutamate synthase, small subunit; TIGRFAM: Glutamate synthase (NADPH), homotetrameric; IMG reference gene:2503875949; PFAM: Pyridine nucleotide-d [...] | COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146; KEGG: pru:PRU_2071 putative glutamine synthetase; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp; SPTR: Glutamine synthetase, catalytic domain protein; IMG reference gene:2503874221; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain. | 0.763 |
| EGN57299.1 | EGN56504.1 | Premu_1896 | Premu_1064 | COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR006004:IPR001433:IPR019480:IPR013027; KEGG: pmz:HMPREF0659_A6962 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Oxidoreductase FAD/NAD(P)-binding; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; PRIAM: Glutamate synthase (NADPH); SPTR: Glutamate synthase, small subunit; TIGRFAM: Glutamate synthase (NADPH), homotetrameric; IMG reference gene:2503875949; PFAM: Pyridine nucleotide-d [...] | Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: pru:PRU_1960 glutamate synthase large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase, large subunit; IMG reference gene:2503875102; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | 0.999 |
| EGN57299.1 | EGN57625.1 | Premu_1896 | Premu_2238 | COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR006004:IPR001433:IPR019480:IPR013027; KEGG: pmz:HMPREF0659_A6962 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Oxidoreductase FAD/NAD(P)-binding; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; PRIAM: Glutamate synthase (NADPH); SPTR: Glutamate synthase, small subunit; TIGRFAM: Glutamate synthase (NADPH), homotetrameric; IMG reference gene:2503875949; PFAM: Pyridine nucleotide-d [...] | L-glutamine synthetase; COGs: COG3968 Uncharacterized protein related to glutamine synthetase; InterPro IPR008146; KEGG: pmz:HMPREF0659_A5221 glutamate--ammonia ligase, catalytic domain protein; PFAM: Glutamine synthetase, catalytic domain; SPTR: Type III glutamine synthetase; IMG reference gene:2503876304; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase type III N terminal. | 0.764 |