Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EGN58157.1PfkB domain protein; InterPro IPR011611; KEGG: pru:PRU_0873 putative 2-dehydro-3-deoxygluconokinase; PFAM: Carbohydrate/purine kinase; SPTR: PfkB family KHG/KDPG family aldolase/carbohydrate kinase; IMG reference gene:2503876891; PFAM: pfkB family carbohydrate kinase. (118 aa)    
Predicted Functional Partners:
EGN57153.1
COGs: COG0036 Pentose-5-phosphate-3-epimerase; InterPro IPR000056; KEGG: pru:PRU_0232 ribulose-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; SPTR: Ribulose-phosphate 3-epimerase; TIGRFAM: Ribulose-phosphate 3-epimerase; IMG reference gene:2503875794; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase.
  
 0.764
EGN57735.1
Xylulokinase; COGs: COG1070 Sugar (pentulose and hexulose) kinase; InterPro IPR018484:IPR018485; KEGG: pru:PRU_1379 putative xylulokinase; PFAM: Carbohydrate kinase, FGGY, N-terminal; Carbohydrate kinase, FGGY, C-terminal; PRIAM: Xylulokinase; SPTR: Putative uncharacterized protein; IMG reference gene:2503876423; PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain.
 
 
 0.668
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
 
 0.657
EGN56977.1
COGs: COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; InterPro IPR006148:IPR003737; KEGG: pmz:HMPREF0659_A6972 glucosamine-6-phosphate deaminase-like protein; PFAM: Glucosamine/galactosamine-6-phosphate isomerase; N-acetylglucosaminyl phosphatidylinositol deacetylase; PRIAM: Glucosamine-6-phosphate deaminase; SPTR: Glucosamine-6-phosphate deaminase-like protein; IMG reference gene:2503875610; PFAM: Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase; GlcNAc-PI de-N-acetylase; TIGRFAM: glucosamine-6-phosphate isomerase.
  
 
 0.654
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.617
EGN56345.1
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; COGs: COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase; HAMAP: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; InterPro IPR001228; KEGG: bth:BT_2881 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; SPTR: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; IMG reference gene:2503874919; PFAM: Uncharacterized protein family UPF0007; TIGRFAM: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Belongs to the IspD/TarI cytidylyltransferase fa [...]
     
  0.549
ispD
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
     
  0.549
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 0.548
EGN58158.1
Protein of unknown function DUF187; COGs: COG1649 conserved hypothetical protein; InterPro IPR003790; KEGG: phe:Phep_4123 protein of unknown function DUF187; PFAM: Protein of unknown function DUF187; SPTR: FenI; IMG reference gene:2503876892; PFAM: Uncharacterised BCR, COG1649.
       0.527
EGN57178.1
Oxidoreductase domain protein; COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683; KEGG: scb:SCAB_23401 putative bi-domain oxidoreductase; PFAM: Oxidoreductase, N-terminal; SPTR: NAD-binding oxidoreductase; IMG reference gene:2503875819; PFAM: Oxidoreductase family, NAD-binding Rossmann fold.
  
 
 0.524
Your Current Organism:
Prevotella multisaccharivorax
NCBI taxonomy Id: 688246
Other names: P. multisaccharivorax DSM 17128, Prevotella multisaccharivorax DSM 17128, Prevotella multisaccharivorax JCM 12954, Prevotella multisaccharivorax str. DSM 17128, Prevotella multisaccharivorax strain DSM 17128
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