STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
AEH50115.1Prepilin peptidase; COGs: COG1989 Type II secretory pathway prepilin signal peptidase PulO and related peptidase; InterPro IPR010627:IPR000045; KEGG: tle:Tlet_0007 peptidase A24A domain-containing protein; PFAM: peptidase A24A domain protein; peptidase A24A prepilin type IV; PRIAM: Prepilin peptidase; SPTR: Peptidase A24A domain protein; PFAM: Bacterial Peptidase A24 N-terminal domain; Type IV leader peptidase family. (247 aa)    
Predicted Functional Partners:
AEH51302.1
COGs: COG2804 Type II secretory pathway ATPase PulE/Tfp pilus assembly pathway ATPase PilB; InterPro IPR001482:IPR003593:IPR007831; KEGG: tle:Tlet_1052 type II secretion system protein E; PFAM: type II secretion system protein E; General secretory system II protein E domain protein; SMART: AAA ATPase; SPTR: Type II secretion system protein E; PFAM: Type II/IV secretion system protein; GSPII_E N-terminal domain.
 
 
 0.904
AEH50967.1
Type II secretion system F domain protein; COGs: COG1459 Type II secretory pathway component PulF; InterPro IPR018076:IPR003004; KEGG: tle:Tlet_0504 type II secretion system protein; PFAM: Type II secretion system F domain; SPTR: Type II secretion system protein; PFAM: Bacterial type II secretion system protein F domain.
 
  
 0.901
nnrD
Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...]
       0.846
AEH51717.1
Twitching motility protein; COGs: COG2805 Tfp pilus assembly protein pilus retraction ATPase PilT; InterPro IPR003593:IPR006321:IPR001482; KEGG: tle:Tlet_0381 twitching motility protein; PFAM: type II secretion system protein E; SMART: AAA ATPase; SPTR: Twitching motility protein; TIGRFAM: twitching motility protein; PFAM: Type II/IV secretion system protein; TIGRFAM: pilus retraction protein PilT.
 
   
 0.839
AEH50116.1
InterPro IPR019734:IPR013026:IPR001440; KEGG: tle:Tlet_0008 TPR repeat-containing protein; PFAM: Tetratricopeptide TPR_1 repeat-containing protein; SPTR: Tetratricopeptide TPR_2 repeat protein; PFAM: Tetratricopeptide repeat.
     
 0.834
AEH50112.1
InterPro IPR011716; KEGG: tle:Tlet_0004 tetratricopeptide TPR_3; PFAM: Tetratricopeptide TPR_3 repeat-containing protein; SPTR: Tetratricopeptide TPR_3.
       0.809
AEH50114.1
COGs: COG0741 Soluble lytic murein transglycosylase and related regulatory protein (some contain LysM/invasin domains); InterPro IPR008258; KEGG: tle:Tlet_0006 lytic transglycosylase catalytic; PFAM: Lytic transglycosylase catalytic; SPTR: Lytic transglycosylase catalytic; PFAM: Transglycosylase SLT domain.
       0.809
gpsA
COGs: COG0240 Glycerol-3-phosphate dehydrogenase; InterPro IPR006168:IPR011128:IPR006109; KEGG: tle:Tlet_0002 glycerol-3-phosphate dehydrogenase (NAD(P)(+)); PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; SPTR: Glycerol-3-phosphate dehydrogenase; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
       0.803
trmB
tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
       0.803
AEH51346.1
DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: tle:Tlet_0292 DNA protecting protein DprA; PFAM: SMF family protein; SPTR: DNA protecting protein DprA; TIGRFAM: DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA.
  
  
 0.705
Your Current Organism:
Pseudothermotoga thermarum
NCBI taxonomy Id: 688269
Other names: P. thermarum DSM 5069, Pseudothermotoga thermarum DSM 5069, Pseudothermotoga thermarum LA3, Pseudothermotoga thermarum str. DSM 5069, Pseudothermotoga thermarum strain DSM 5069, Thermotoga thermarum DSM 5069, Thermotoga thermarum LA3
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