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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH50890.1SMC domain protein; COGs: COG0419 ATPase involved in DNA repair; InterPro IPR003395; KEGG: tle:Tlet_0413 SMC domain-containing protein; PFAM: SMC domain protein; SPTR: SMC domain protein. (847 aa)    
Predicted Functional Partners:
sbcD
Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
 
 0.999
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.973
AEH50889.1
HEAT domain containing protein; InterPro IPR000357:IPR021133; KEGG: tle:Tlet_0412 heat domain-containing protein; PFAM: HEAT domain containing protein; SPTR: HEAT domain containing protein; PFAM: HEAT repeat.
       0.827
panB
Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
       0.788
AEH50893.1
Domain of unknown function DUF2520; COGs: COG5495 conserved hypothetical protein; InterPro IPR018931; KEGG: tle:Tlet_0416 hypothetical protein; PFAM: Domain of unknown function DUF2520; SPTR: Putative uncharacterized protein; PFAM: Domain of unknown function (DUF2520); NADP oxidoreductase coenzyme F420-dependent.
       0.788
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.693
AEH50691.1
Hypothetical protein; COGs: COG0433 ATPase; KEGG: tle:Tlet_1381 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.601
AEH50894.1
PP-loop domain protein; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; InterPro IPR011063:IPR012089; KEGG: tle:Tlet_0417 thiamine biosynthesis protein; PFAM: PP-loop domain protein; SPTR: Thiamine biosynthesis protein; PFAM: PP-loop family; TIGRFAM: conserved hypothetical protein TIGR00269; Belongs to the TtcA family.
       0.551
AEH50895.1
Cell cycle protein; COGs: COG0772 Bacterial cell division membrane protein; InterPro IPR001182:IPR018365; KEGG: tle:Tlet_0418 cell cycle protein; PFAM: cell cycle protein; SPTR: Cell cycle protein; PFAM: Cell cycle protein; TIGRFAM: rod shape-determining protein RodA; Belongs to the SEDS family.
       0.551
AEH50896.1
KEGG: tle:Tlet_0419 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.551
Your Current Organism:
Pseudothermotoga thermarum
NCBI taxonomy Id: 688269
Other names: P. thermarum DSM 5069, Pseudothermotoga thermarum DSM 5069, Pseudothermotoga thermarum LA3, Pseudothermotoga thermarum str. DSM 5069, Pseudothermotoga thermarum strain DSM 5069, Thermotoga thermarum DSM 5069, Thermotoga thermarum LA3
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