STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
sbcDNuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (366 aa)    
Predicted Functional Partners:
AEH50890.1
SMC domain protein; COGs: COG0419 ATPase involved in DNA repair; InterPro IPR003395; KEGG: tle:Tlet_0413 SMC domain-containing protein; PFAM: SMC domain protein; SPTR: SMC domain protein.
 
 0.998
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.988
AEH50240.1
COGs: COG3833 ABC-type maltose transport systems permease component; InterPro IPR000515; KEGG: tna:CTN_1369 maltose ABC transporter, permease protein; PFAM: binding-protein-dependent transport systems inner membrane component; SPTR: Maltose ABC transporter, permease protein; PFAM: Binding-protein-dependent transport system inner membrane component.
  
 0.951
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.868
AEH50893.1
Domain of unknown function DUF2520; COGs: COG5495 conserved hypothetical protein; InterPro IPR018931; KEGG: tle:Tlet_0416 hypothetical protein; PFAM: Domain of unknown function DUF2520; SPTR: Putative uncharacterized protein; PFAM: Domain of unknown function (DUF2520); NADP oxidoreductase coenzyme F420-dependent.
 
     0.831
AEH50889.1
HEAT domain containing protein; InterPro IPR000357:IPR021133; KEGG: tle:Tlet_0412 heat domain-containing protein; PFAM: HEAT domain containing protein; SPTR: HEAT domain containing protein; PFAM: HEAT repeat.
       0.819
panB
Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
       0.808
AEH51465.1
Helicase domain protein; COGs: COG0553 Superfamily II DNA/RNA helicase SNF2 family; InterPro IPR014001:IPR001650:IPR014021:IPR000330; KEGG: tal:Thal_1590 helicase domain protein; PFAM: helicase domain protein; SNF2-related protein; SMART: helicase domain protein; DEAD-like helicase; SPTR: Helicase domain protein; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain.
  
 
 0.799
AEH50646.1
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212:IPR014016:IPR014017; KEGG: tle:Tlet_0935 UvrD/REP helicase; PFAM: UvrD/REP helicase; SPTR: UvrD/REP helicase; PFAM: UvrD/REP helicase.
   
 
 0.796
AEH50408.1
1-Cys peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
 
 0.714
Your Current Organism:
Pseudothermotoga thermarum
NCBI taxonomy Id: 688269
Other names: P. thermarum DSM 5069, Pseudothermotoga thermarum DSM 5069, Pseudothermotoga thermarum LA3, Pseudothermotoga thermarum str. DSM 5069, Pseudothermotoga thermarum strain DSM 5069, Thermotoga thermarum DSM 5069, Thermotoga thermarum LA3
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