Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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AEH51149.1Uncharacterized protein family UPF0102; COGs: COG0792 endonuclease distantly related to Holliday junction resolvase; InterPro IPR003509; KEGG: tle:Tlet_0667 hypothetical protein; PFAM: Uncharacterised protein family UPF0102; SPTR: UPF0102 protein Tlet_0667; PFAM: Uncharacterised protein family UPF0102. (108 aa)    
Predicted Functional Partners:
gatC
aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family.
  
    0.824
AEH51145.1
COGs: COG1344 Flagellin and related hook-associated protein; InterPro IPR013384:IPR001492; KEGG: tle:Tlet_0671 flagellar hook-associated protein 3; PFAM: flagellin domain protein; SPTR: Flagellar hook-associated protein 3; TIGRFAM: flagellar hook-associated protein 3; PFAM: Bacterial flagellin N-terminal helical region; TIGRFAM: flagellar hook-associated protein 3.
  
    0.818
csrA
Carbon storage regulator, CsrA; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
       0.818
fliW
Protein of unknown function DUF180; Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
       0.812
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
  
    0.807
AEH51144.1
COGs: COG1256 Flagellar hook-associated protein; InterPro IPR002371:IPR001444:IPR010930; KEGG: tle:Tlet_0672 flagellar hook-associated protein FlgK; PFAM: protein of unknown function DUF1078 domain protein; flagellar basal body rod protein; SPTR: Flagellar hook-associated protein FlgK; TIGRFAM: flagellar hook-associated protein FlgK; PFAM: Domain of unknown function (DUF1078); TIGRFAM: flagellar hook-associated protein FlgK.
  
    0.798
AEH51156.1
Sigma-54 DNA-binding domain protein; COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; InterPro IPR000394:IPR007634; KEGG: tle:Tlet_0660 sigma-54 DNA-binding domain-containing protein; PFAM: sigma-54 DNA-binding domain protein; SPTR: Sigma-54 DNA-binding domain protein; PFAM: Sigma-54 factor, core binding domain; Sigma-54, DNA binding domain.
       0.766
AEH51159.1
Peptidase M50; COGs: COG0750 membrane-associated Zn-dependent protease 1; InterPro IPR001478:IPR008915; KEGG: tle:Tlet_0657 peptidase M50; PFAM: peptidase M50; SMART: PDZ/DHR/GLGF domain protein; SPTR: Peptidase M50; PFAM: Peptidase family M50; PDZ domain (Also known as DHR or GLGF); TIGRFAM: RIP metalloprotease RseP.
       0.761
dxr
1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
       0.760
AEH51151.1
Ribosomal large subunit pseudouridine synthase C; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.
       0.759
Your Current Organism:
Pseudothermotoga thermarum
NCBI taxonomy Id: 688269
Other names: P. thermarum DSM 5069, Pseudothermotoga thermarum DSM 5069, Pseudothermotoga thermarum LA3, Pseudothermotoga thermarum str. DSM 5069, Pseudothermotoga thermarum strain DSM 5069, Thermotoga thermarum DSM 5069, Thermotoga thermarum LA3
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