Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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[Homology]
Score
AEH51153.1KEGG: tle:Tlet_0663 hypothetical protein; SPTR: Putative uncharacterized protein. (436 aa)    
Predicted Functional Partners:
AEH51151.1
Ribosomal large subunit pseudouridine synthase C; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.
       0.822
AEH51152.1
KEGG: tle:Tlet_0664 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.813
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
     
 0.810
queA
S-adenosylmethionine--tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
       0.808
AEH51154.1
KEGG: tle:Tlet_0662 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.807
AEH51847.1
Polysaccharide pyruvyl transferase; COGs: COG2327 conserved hypothetical protein; KEGG: tle:Tlet_1829 polysaccharide pyruvyl transferase; SPTR: Polysaccharide pyruvyl transferase; PFAM: Polysaccharide pyruvyl transferase; TIGRFAM: polysaccharide pyruvyl transferase CsaB.
 
  
 0.799
AEH51159.1
Peptidase M50; COGs: COG0750 membrane-associated Zn-dependent protease 1; InterPro IPR001478:IPR008915; KEGG: tle:Tlet_0657 peptidase M50; PFAM: peptidase M50; SMART: PDZ/DHR/GLGF domain protein; SPTR: Peptidase M50; PFAM: Peptidase family M50; PDZ domain (Also known as DHR or GLGF); TIGRFAM: RIP metalloprotease RseP.
  
    0.787
AEH51144.1
COGs: COG1256 Flagellar hook-associated protein; InterPro IPR002371:IPR001444:IPR010930; KEGG: tle:Tlet_0672 flagellar hook-associated protein FlgK; PFAM: protein of unknown function DUF1078 domain protein; flagellar basal body rod protein; SPTR: Flagellar hook-associated protein FlgK; TIGRFAM: flagellar hook-associated protein FlgK; PFAM: Domain of unknown function (DUF1078); TIGRFAM: flagellar hook-associated protein FlgK.
 
     0.784
ispG
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
  
    0.771
AEH51156.1
Sigma-54 DNA-binding domain protein; COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; InterPro IPR000394:IPR007634; KEGG: tle:Tlet_0660 sigma-54 DNA-binding domain-containing protein; PFAM: sigma-54 DNA-binding domain protein; SPTR: Sigma-54 DNA-binding domain protein; PFAM: Sigma-54 factor, core binding domain; Sigma-54, DNA binding domain.
       0.770
Your Current Organism:
Pseudothermotoga thermarum
NCBI taxonomy Id: 688269
Other names: P. thermarum DSM 5069, Pseudothermotoga thermarum DSM 5069, Pseudothermotoga thermarum LA3, Pseudothermotoga thermarum str. DSM 5069, Pseudothermotoga thermarum strain DSM 5069, Thermotoga thermarum DSM 5069, Thermotoga thermarum LA3
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