Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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AEH52003.1FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR013221:IPR004101:IPR001645; KEGG: tle:Tlet_1984 FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; PRIAM: Tetrahydrofolate synthase; SPTR: FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase. (440 aa)    
Predicted Functional Partners:
AEH50354.1
COGs: COG0294 Dihydropteroate synthase; InterPro IPR006390:IPR000489; KEGG: tle:Tlet_0902 dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS; PRIAM: Dihydropteroate synthase; SPTR: Dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: Pterin binding enzyme; TIGRFAM: dihydropteroate synthase.
 
 0.996
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
  
  
 0.888
ruvA
Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
       0.822
AEH52005.1
KEGG: tle:Tlet_1986 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.808
acpS
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family.
 
  
 0.748
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.661
AEH52001.1
KEGG: tle:Tlet_1982 hypothetical protein; SPTR: Putative uncharacterized protein.
     
 0.642
fhs
Formate-tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR000559:IPR020628; KEGG: tle:Tlet_1513 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: Formate--tetrahydrofolate ligase; PFAM: Formate--tetrahydrofolate ligase.
  
 
 0.637
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
 
  
 0.637
AEH52000.1
Protein of unknown function DUF2089; COGs: COG3877 conserved hypothetical protein; InterPro IPR018658; KEGG: tle:Tlet_1981 uncharacterized conserved protein, containing Zn finger; PFAM: Protein of unknown function DUF2089; SPTR: Uncharacterized consrved protein, containing Zn finger; PFAM: Protein of unknown function(DUF2089).
       0.605
Your Current Organism:
Pseudothermotoga thermarum
NCBI taxonomy Id: 688269
Other names: P. thermarum DSM 5069, Pseudothermotoga thermarum DSM 5069, Pseudothermotoga thermarum LA3, Pseudothermotoga thermarum str. DSM 5069, Pseudothermotoga thermarum strain DSM 5069, Thermotoga thermarum DSM 5069, Thermotoga thermarum LA3
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