| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gcl_1 | ilvD | VME0621_01979 | VME0621_04969 | Glyoxylate carboligase. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.498 |
| gcl_1 | ilvH | VME0621_01979 | VME0621_04133 | Glyoxylate carboligase. | Acetolactate synthase isozyme 3 small subunit. | 0.482 |
| gcl_1 | ipdC | VME0621_01979 | VME0621_04832 | Glyoxylate carboligase. | Indole-3-pyruvate decarboxylase. | 0.536 |
| gcl_1 | leuB | VME0621_01979 | VME0621_02250 | Glyoxylate carboligase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.473 |
| gcvA_11 | ipdC | VME0621_04833 | VME0621_04832 | Glycine cleavage system transcriptional activator. | Indole-3-pyruvate decarboxylase. | 0.505 |
| guaB_2 | gutQ | VME0621_04505 | VME0621_03384 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Arabinose 5-phosphate isomerase GutQ. | 0.408 |
| guaB_2 | hemF | VME0621_04505 | VME0621_05241 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.423 |
| guaB_2 | ilvD | VME0621_04505 | VME0621_04969 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.412 |
| guaB_2 | ipdC | VME0621_04505 | VME0621_04832 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Indole-3-pyruvate decarboxylase. | 0.604 |
| guaB_2 | leuB | VME0621_04505 | VME0621_02250 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.570 |
| guaB_2 | pgk | VME0621_04505 | VME0621_02118 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. | 0.491 |
| guaB_2 | pheA | VME0621_04505 | VME0621_04066 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | P-protein. | 0.527 |
| gutQ | guaB_2 | VME0621_03384 | VME0621_04505 | Arabinose 5-phosphate isomerase GutQ. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.408 |
| gutQ | ipdC | VME0621_03384 | VME0621_04832 | Arabinose 5-phosphate isomerase GutQ. | Indole-3-pyruvate decarboxylase. | 0.604 |
| gutQ | leuB | VME0621_03384 | VME0621_02250 | Arabinose 5-phosphate isomerase GutQ. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.434 |
| hemF | guaB_2 | VME0621_05241 | VME0621_04505 | Coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.423 |
| hemF | ipdC | VME0621_05241 | VME0621_04832 | Coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Indole-3-pyruvate decarboxylase. | 0.488 |
| ilvD | gcl_1 | VME0621_04969 | VME0621_01979 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Glyoxylate carboligase. | 0.498 |
| ilvD | guaB_2 | VME0621_04969 | VME0621_04505 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.412 |
| ilvD | ilvH | VME0621_04969 | VME0621_04133 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Acetolactate synthase isozyme 3 small subunit. | 0.948 |