node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GLE_0251 | GLE_3747 | GLE_0251 | GLE_3747 | DNA/pantothenate metabolism flavoprotein. | Aminotransferase class I and II. | 0.636 |
GLE_0251 | birA | GLE_0251 | GLE_4336 | DNA/pantothenate metabolism flavoprotein. | biotin-[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.622 |
GLE_0251 | coaBC | GLE_0251 | GLE_0252 | DNA/pantothenate metabolism flavoprotein. | DNA/pantothenate metabolism flavoprotein. | 0.999 |
GLE_0251 | coaD | GLE_0251 | GLE_3532 | DNA/pantothenate metabolism flavoprotein. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.937 |
GLE_0251 | coaX | GLE_0251 | GLE_4335 | DNA/pantothenate metabolism flavoprotein. | Transcriptional activator, putative, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.919 |
GLE_0251 | dut | GLE_0251 | GLE_0253 | DNA/pantothenate metabolism flavoprotein. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.985 |
GLE_0251 | panC | GLE_0251 | GLE_3174 | DNA/pantothenate metabolism flavoprotein. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.767 |
GLE_0251 | priA | GLE_0251 | GLE_4865 | DNA/pantothenate metabolism flavoprotein. | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.527 |
GLE_3747 | GLE_0251 | GLE_3747 | GLE_0251 | Aminotransferase class I and II. | DNA/pantothenate metabolism flavoprotein. | 0.636 |
GLE_3747 | coaBC | GLE_3747 | GLE_0252 | Aminotransferase class I and II. | DNA/pantothenate metabolism flavoprotein. | 0.739 |
birA | GLE_0251 | GLE_4336 | GLE_0251 | biotin-[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | DNA/pantothenate metabolism flavoprotein. | 0.622 |
birA | coaBC | GLE_4336 | GLE_0252 | biotin-[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | DNA/pantothenate metabolism flavoprotein. | 0.622 |
birA | coaD | GLE_4336 | GLE_3532 | biotin-[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.656 |
birA | coaX | GLE_4336 | GLE_4335 | biotin-[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Transcriptional activator, putative, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.972 |
birA | panC | GLE_4336 | GLE_3174 | biotin-[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.793 |
coaBC | GLE_0251 | GLE_0252 | GLE_0251 | DNA/pantothenate metabolism flavoprotein. | DNA/pantothenate metabolism flavoprotein. | 0.999 |
coaBC | GLE_3747 | GLE_0252 | GLE_3747 | DNA/pantothenate metabolism flavoprotein. | Aminotransferase class I and II. | 0.739 |
coaBC | birA | GLE_0252 | GLE_4336 | DNA/pantothenate metabolism flavoprotein. | biotin-[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.622 |
coaBC | coaD | GLE_0252 | GLE_3532 | DNA/pantothenate metabolism flavoprotein. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.937 |
coaBC | coaX | GLE_0252 | GLE_4335 | DNA/pantothenate metabolism flavoprotein. | Transcriptional activator, putative, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.919 |