Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (430 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase; Belongs to the GPI family.
  
 0.986
pyk
Pyruvate kinase; Belongs to the pyruvate kinase family.
 
 
 0.928
tktA
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
  
 0.914
fbp
Fructose-1,6-bisphosphatase; Belongs to the FBPase class 1 family.
    
 0.913
talA
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
   
 0.907
fba
Fructose-bisphosphate aldolase.
  
 0.900
manA
Mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 2 family.
    
 0.898
scrK
Fructokinase-1.
   
 0.893
eno
Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
  
  
 0.888
lacD
D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit.
     
 0.878
Your Current Organism:
Lysobacter enzymogenes
NCBI taxonomy Id: 69
Other names: ATCC 29487, DSM 2043, L. enzymogenes, LMG 8762, LMG:8762, Lysobacter enzymogenes subsp. enzymogenes, UASM 495
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