node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GLE_0829 | GLE_4250 | GLE_0829 | GLE_4250 | Aspartate kinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Pyridoxal-phosphate dependent enzyme/CBS domain pair. | 0.947 |
GLE_0829 | ahcY | GLE_0829 | GLE_1033 | Aspartate kinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.899 |
GLE_0829 | mdeA | GLE_0829 | GLE_4248 | Aspartate kinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Methionine gamma-lyase. | 0.962 |
GLE_0829 | metB | GLE_0829 | GLE_1123 | Aspartate kinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | O-succinylhomoserine (thiol)-lyase. | 0.971 |
GLE_0829 | metE | GLE_0829 | GLE_0965 | Aspartate kinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.964 |
GLE_0829 | metF | GLE_0829 | GLE_1029 | Aspartate kinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.948 |
GLE_0829 | metG | GLE_0829 | GLE_3161 | Aspartate kinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.594 |
GLE_0829 | metH | GLE_0829 | GLE_2694 | Aspartate kinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Methionine synthase. | 0.948 |
GLE_0829 | metH-2 | GLE_0829 | GLE_2695 | Aspartate kinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.949 |
GLE_0829 | metK | GLE_0829 | GLE_1041 | Aspartate kinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.671 |
GLE_4250 | GLE_0829 | GLE_4250 | GLE_0829 | Pyridoxal-phosphate dependent enzyme/CBS domain pair. | Aspartate kinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.947 |
GLE_4250 | ahcY | GLE_4250 | GLE_1033 | Pyridoxal-phosphate dependent enzyme/CBS domain pair. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.932 |
GLE_4250 | mdeA | GLE_4250 | GLE_4248 | Pyridoxal-phosphate dependent enzyme/CBS domain pair. | Methionine gamma-lyase. | 0.997 |
GLE_4250 | metB | GLE_4250 | GLE_1123 | Pyridoxal-phosphate dependent enzyme/CBS domain pair. | O-succinylhomoserine (thiol)-lyase. | 0.994 |
GLE_4250 | metE | GLE_4250 | GLE_0965 | Pyridoxal-phosphate dependent enzyme/CBS domain pair. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.936 |
GLE_4250 | metF | GLE_4250 | GLE_1029 | Pyridoxal-phosphate dependent enzyme/CBS domain pair. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.754 |
GLE_4250 | metH | GLE_4250 | GLE_2694 | Pyridoxal-phosphate dependent enzyme/CBS domain pair. | Methionine synthase. | 0.919 |
GLE_4250 | metH-2 | GLE_4250 | GLE_2695 | Pyridoxal-phosphate dependent enzyme/CBS domain pair. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.915 |
GLE_4250 | metK | GLE_4250 | GLE_1041 | Pyridoxal-phosphate dependent enzyme/CBS domain pair. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.411 |
ahcY | GLE_0829 | GLE_1033 | GLE_0829 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Aspartate kinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.899 |