GLE_2686 protein (Lysobacter enzymogenes) - STRING interaction network

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Score

GLE_2686

5'-nucleotidase. (306 aa)

Predicted Functional Partners:

GLE_0729

0.947

guaB

0.933

GLE_4103

0.891

tdk

0.872

GLE_0127

0.872

dut

0.872

purH

0.872

adk

0.872

rdgB

0.872

gmk

0.872

Your Current Organism:

Lysobacter enzymogenes

NCBI taxonomy Id: 69
Other names: ATCC 29487, DSM 2043, L. enzymogenes, LMG 8762, LMG:8762, Lysobacter enzymogenes subsp. enzymogenes, UASM 495

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GLE_0127	GLE_2686	GLE_0127	GLE_2686	Glutamine amidotransferase class-I.	5'-nucleotidase.	0.872
GLE_0127	gmk	GLE_0127	GLE_0910	Glutamine amidotransferase class-I.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.886
GLE_0127	guaB	GLE_0127	GLE_2894	Glutamine amidotransferase class-I.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.955
GLE_0127	rdgB	GLE_0127	GLE_0906	Glutamine amidotransferase class-I.	Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.872
GLE_0729	GLE_2686	GLE_0729	GLE_2686	NADH pyrophosphatase-like rudimentary NUDIX domain protein; Belongs to the Nudix hydrolase family.	5'-nucleotidase.	0.947
GLE_2686	GLE_0127	GLE_2686	GLE_0127	5'-nucleotidase.	Glutamine amidotransferase class-I.	0.872
GLE_2686	GLE_0729	GLE_2686	GLE_0729	5'-nucleotidase.	NADH pyrophosphatase-like rudimentary NUDIX domain protein; Belongs to the Nudix hydrolase family.	0.947
GLE_2686	GLE_4103	GLE_2686	GLE_4103	5'-nucleotidase.	Hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family.	0.891
GLE_2686	adk	GLE_2686	GLE_0857	5'-nucleotidase.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	0.872
GLE_2686	dut	GLE_2686	GLE_0253	5'-nucleotidase.	dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	0.872
GLE_2686	gmk	GLE_2686	GLE_0910	5'-nucleotidase.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.872
GLE_2686	guaB	GLE_2686	GLE_2894	5'-nucleotidase.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.933
GLE_2686	purH	GLE_2686	GLE_0749	5'-nucleotidase.	Bifunctional purine biosynthesis protein PurH.	0.872
GLE_2686	rdgB	GLE_2686	GLE_0906	5'-nucleotidase.	Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.872
GLE_2686	tdk	GLE_2686	GLE_0089	5'-nucleotidase.	Thymidine kinase.	0.872
GLE_4103	GLE_2686	GLE_4103	GLE_2686	Hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family.	5'-nucleotidase.	0.891
adk	GLE_2686	GLE_0857	GLE_2686	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	5'-nucleotidase.	0.872
adk	dut	GLE_0857	GLE_0253	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	0.721
adk	gmk	GLE_0857	GLE_0910	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.873
adk	guaB	GLE_0857	GLE_2894	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.864