STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metXHomoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine. (386 aa)    
Predicted Functional Partners:
GLE_0829
Aspartate kinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.940
metB
O-succinylhomoserine (thiol)-lyase.
  
 0.940
GLE_1124
Homoserine dehydrogenase.
 
 
 0.937
GLE_1122
Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family.
  
  
 
0.905
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
     
 0.880
GLE_4250
Pyridoxal-phosphate dependent enzyme/CBS domain pair.
    
 0.880
pssA
CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
  
  
  0.877
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.877
sdaA
L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family.
     
  0.860
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.860
Your Current Organism:
Lysobacter enzymogenes
NCBI taxonomy Id: 69
Other names: ATCC 29487, DSM 2043, L. enzymogenes, LMG 8762, LMG:8762, Lysobacter enzymogenes subsp. enzymogenes, UASM 495
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