guaA protein (Lysobacter enzymogenes) - STRING interaction network

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Score

guaA

GMP synthase; Catalyzes the synthesis of GMP from XMP. (522 aa)

Predicted Functional Partners:

guaB

0.999

purL

0.981

gmk

0.976

apt

0.962

argS

0.959

pyrG

0.959

GLE_1197

0.950

hpt

0.948

rdgB

0.944

rplK

0.943

Your Current Organism:

Lysobacter enzymogenes

NCBI taxonomy Id: 69
Other names: ATCC 29487, DSM 2043, L. enzymogenes, LMG 8762, LMG:8762, Lysobacter enzymogenes subsp. enzymogenes, UASM 495

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GLE_1197	apt	GLE_1197	GLE_3892	Arabinose 5-phosphate isomerase.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.651
GLE_1197	gmk	GLE_1197	GLE_0910	Arabinose 5-phosphate isomerase.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.583
GLE_1197	guaA	GLE_1197	GLE_2893	Arabinose 5-phosphate isomerase.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.950
GLE_1197	guaB	GLE_1197	GLE_2894	Arabinose 5-phosphate isomerase.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.960
GLE_1197	hpt	GLE_1197	GLE_1719	Arabinose 5-phosphate isomerase.	Hypoxanthine phosphoribosyltransferase.	0.698
GLE_1197	purL	GLE_1197	GLE_4186	Arabinose 5-phosphate isomerase.	Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.	0.842
GLE_1197	pyrG	GLE_1197	GLE_1483	Arabinose 5-phosphate isomerase.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.492
apt	GLE_1197	GLE_3892	GLE_1197	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Arabinose 5-phosphate isomerase.	0.651
apt	gmk	GLE_3892	GLE_0910	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.751
apt	guaA	GLE_3892	GLE_2893	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.962
apt	guaB	GLE_3892	GLE_2894	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.920
apt	hpt	GLE_3892	GLE_1719	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Hypoxanthine phosphoribosyltransferase.	0.648
apt	purL	GLE_3892	GLE_4186	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.	0.867
apt	pyrG	GLE_3892	GLE_1483	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.458
apt	rdgB	GLE_3892	GLE_0906	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.755
argS	gmk	GLE_0249	GLE_0910	arginyl-tRNA synthetase.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.489
argS	guaA	GLE_0249	GLE_2893	arginyl-tRNA synthetase.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.959
argS	purL	GLE_0249	GLE_4186	arginyl-tRNA synthetase.	Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.	0.690
argS	pyrG	GLE_0249	GLE_1483	arginyl-tRNA synthetase.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.858
argS	rplK	GLE_0249	GLE_3801	arginyl-tRNA synthetase.	Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.526