gvcR protein (Lysobacter enzymogenes) - STRING interaction network

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Score

gvcR

Glycine cleavage system transcriptional repressor. (186 aa)

Predicted Functional Partners:

GLE_3185

0.858

gcvP

0.817

metG

0.771

dapA

0.740

GLE_2875

0.731

metH

0.711

metH-2

0.711

glyA

0.711

GLE_4250

0.676

GLE_0929

0.672

Your Current Organism:

Lysobacter enzymogenes

NCBI taxonomy Id: 69
Other names: ATCC 29487, DSM 2043, L. enzymogenes, LMG 8762, LMG:8762, Lysobacter enzymogenes subsp. enzymogenes, UASM 495

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GLE_0929	GLE_2875	GLE_0929	GLE_2875	Hypothetical protein.	Hypothetical protein.	0.701
GLE_0929	gvcR	GLE_0929	GLE_3184	Hypothetical protein.	Glycine cleavage system transcriptional repressor.	0.672
GLE_2875	GLE_0929	GLE_2875	GLE_0929	Hypothetical protein.	Hypothetical protein.	0.701
GLE_2875	gvcR	GLE_2875	GLE_3184	Hypothetical protein.	Glycine cleavage system transcriptional repressor.	0.731
GLE_3185	dapA	GLE_3185	GLE_3183	Antioxidant, AhpC/TSA family.	Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).	0.627
GLE_3185	gvcR	GLE_3185	GLE_3184	Antioxidant, AhpC/TSA family.	Glycine cleavage system transcriptional repressor.	0.858
GLE_4250	glyA	GLE_4250	GLE_4161	Pyridoxal-phosphate dependent enzyme/CBS domain pair.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.919
GLE_4250	gvcR	GLE_4250	GLE_3184	Pyridoxal-phosphate dependent enzyme/CBS domain pair.	Glycine cleavage system transcriptional repressor.	0.676
GLE_4250	metH	GLE_4250	GLE_2694	Pyridoxal-phosphate dependent enzyme/CBS domain pair.	Methionine synthase.	0.892
GLE_4250	metH-2	GLE_4250	GLE_2695	Pyridoxal-phosphate dependent enzyme/CBS domain pair.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.890
dapA	GLE_3185	GLE_3183	GLE_3185	Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).	Antioxidant, AhpC/TSA family.	0.627
dapA	gvcR	GLE_3183	GLE_3184	Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).	Glycine cleavage system transcriptional repressor.	0.740
gcvP	glyA	GLE_1547	GLE_4161	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.998
gcvP	gvcR	GLE_1547	GLE_3184	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Glycine cleavage system transcriptional repressor.	0.817
gcvP	metH	GLE_1547	GLE_2694	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Methionine synthase.	0.944
gcvP	metH-2	GLE_1547	GLE_2695	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.655
glyA	GLE_4250	GLE_4161	GLE_4250	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Pyridoxal-phosphate dependent enzyme/CBS domain pair.	0.919
glyA	gcvP	GLE_4161	GLE_1547	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.998
glyA	gvcR	GLE_4161	GLE_3184	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Glycine cleavage system transcriptional repressor.	0.711
glyA	metG	GLE_4161	GLE_3161	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	0.596