STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmgAHomogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (460 aa)    
Predicted Functional Partners:
hppD
4-hydroxyphenylpyruvate dioxygenase SEQUENCING GAP.
 
 0.995
maiA
Maleylacetoacetate isomerase.
 
 
 0.959
fahA
Fumarylacetoacetase.
  
 0.945
phhA
Phenylalanine-4-hydroxylase.
 
  
 0.794
GLE_5300
FAD binding domain/FAD dependent oxidoreductase.
 
  
 0.595
GLE_4257
Fumarylacetoacetate hydrolase.
  
  
 0.593
GLE_4306
Transcriptional regulator, MarR family.
 
     0.581
GLE_1001
Fumarylacetoacetate hydrolase domain-containing protein 1.
  
  
 0.572
GLE_5299
Hypothetical protein.
 
     0.536
GLE_4304
Hypothetical protein.
       0.495
Your Current Organism:
Lysobacter enzymogenes
NCBI taxonomy Id: 69
Other names: ATCC 29487, DSM 2043, L. enzymogenes, LMG 8762, LMG:8762, Lysobacter enzymogenes subsp. enzymogenes, UASM 495
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