lipA protein (Lysobacter enzymogenes) - STRING interaction network

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lipA

Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (345 aa)

Predicted Functional Partners:

lipB

0.999

gcvH

0.950

nfuA

0.885

GLE_0677

0.777

GLE_4477

0.738

GLE_0973

0.700

fghA

0.694

sucB

0.686

lpdA

0.657

aceF

0.634

Your Current Organism:

Lysobacter enzymogenes

NCBI taxonomy Id: 69
Other names: ATCC 29487, DSM 2043, L. enzymogenes, LMG 8762, LMG:8762, Lysobacter enzymogenes subsp. enzymogenes, UASM 495

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GLE_0677	aceF	GLE_0677	GLE_0675	Dihydrolipoyl dehydrogenase.	Dihydrolipoyllysine-residue acetyltransferase.	0.995
GLE_0677	gcvH	GLE_0677	GLE_1074	Dihydrolipoyl dehydrogenase.	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.984
GLE_0677	lipA	GLE_0677	GLE_4475	Dihydrolipoyl dehydrogenase.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.777
GLE_0677	lipB	GLE_0677	GLE_4476	Dihydrolipoyl dehydrogenase.	Lipoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.	0.561
GLE_0677	lpdA	GLE_0677	GLE_2725	Dihydrolipoyl dehydrogenase.	Dihydrolipoyl dehydrogenase.	0.978
GLE_0677	nfuA	GLE_0677	GLE_2944	Dihydrolipoyl dehydrogenase.	Iron-sulfur cluster biosynthesis/NifU-like domain; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.	0.456
GLE_0677	sucB	GLE_0677	GLE_2724	Dihydrolipoyl dehydrogenase.	Dihydrolipoyllysine-residue succinyltransferase, E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).	0.999
GLE_0973	lipA	GLE_0973	GLE_4475	Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.700
GLE_4477	lipA	GLE_4477	GLE_4475	UPF0250 protein; Belongs to the UPF0250 family.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.738
GLE_4477	lipB	GLE_4477	GLE_4476	UPF0250 protein; Belongs to the UPF0250 family.	Lipoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.	0.899
aceF	GLE_0677	GLE_0675	GLE_0677	Dihydrolipoyllysine-residue acetyltransferase.	Dihydrolipoyl dehydrogenase.	0.995
aceF	gcvH	GLE_0675	GLE_1074	Dihydrolipoyllysine-residue acetyltransferase.	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.426
aceF	lipA	GLE_0675	GLE_4475	Dihydrolipoyllysine-residue acetyltransferase.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.634
aceF	lipB	GLE_0675	GLE_4476	Dihydrolipoyllysine-residue acetyltransferase.	Lipoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.	0.593
aceF	lpdA	GLE_0675	GLE_2725	Dihydrolipoyllysine-residue acetyltransferase.	Dihydrolipoyl dehydrogenase.	0.999
fghA	lipA	GLE_4840	GLE_4475	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.694
gcvH	GLE_0677	GLE_1074	GLE_0677	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Dihydrolipoyl dehydrogenase.	0.984
gcvH	aceF	GLE_1074	GLE_0675	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Dihydrolipoyllysine-residue acetyltransferase.	0.426
gcvH	lipA	GLE_1074	GLE_4475	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.950
gcvH	lipB	GLE_1074	GLE_4476	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Lipoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.	0.910

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