Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
GLE_4824Aminotransferase, classes I and II superfamily. (472 aa)    
Predicted Functional Partners:
gltB
Glutamine amidotransferases class-II/glutamate synthase.
     
  0.886
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
 
 0.615
GLE_4788
Aminotransferase class I and II/beta-eliminating lyase.
   
  0.587
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
  0.585
ald
Alanine dehydrogenase.
     
  0.582
glnA
Glutamine synthetase, type I.
    
  0.582
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
     
  0.581
lpdA
Dihydrolipoyl dehydrogenase.
     
  0.581
pheA
Chorismate mutase/prephenate dehydratase/ACT domain.
    
 0.581
aceA
Isocitrate lyase.
     
  0.580
Your Current Organism:
Lysobacter enzymogenes
NCBI taxonomy Id: 69
Other names: ATCC 29487, DSM 2043, L. enzymogenes, LMG 8762, LMG:8762, Lysobacter enzymogenes subsp. enzymogenes, UASM 495
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