node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TK0185 | deoA | TK0185 | TK0352 | Translation initiation factor eIF-2B, delta subunit; Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Only accepts the alpha-anomer of D-ribose 1,5-bisphosphate as substrate, being inactive on the beta-anomer. Displays a strict substrate specificity, since other phosphorylated sugars such as R5P, ribose, G16P, G6P, G1P, FBP, F6P, and PRPP, are not substrates. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO. | Thymidine phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP, dCMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. | 0.945 |
TK0185 | thi4 | TK0185 | TK0434 | Translation initiation factor eIF-2B, delta subunit; Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Only accepts the alpha-anomer of D-ribose 1,5-bisphosphate as substrate, being inactive on the beta-anomer. Displays a strict substrate specificity, since other phosphorylated sugars such as R5P, ribose, G16P, G6P, G1P, FBP, F6P, and PRPP, are not substrates. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO. | Thiazole biosynthetic enzyme Thi4; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.747 |
TK0431 | TK0435 | TK0431 | TK0435 | Hypothetical protein, conserved, containing DUF1246 and DUF1297 domains. | Phosphomethylpyrimidine kinase, fused to C-terminal uncharacterized domain. | 0.629 |
TK0431 | TK0436 | TK0431 | TK0436 | Hypothetical protein, conserved, containing DUF1246 and DUF1297 domains. | ABC-type transporter, ATPase component, fused to acetyltransferase domain. | 0.517 |
TK0431 | purC-2 | TK0431 | TK0432 | Hypothetical protein, conserved, containing DUF1246 and DUF1297 domains. | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.938 |
TK0431 | purO | TK0431 | TK0430 | Hypothetical protein, conserved, containing DUF1246 and DUF1297 domains. | Inosine 5'-monophosphate cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | 0.994 |
TK0431 | thi4 | TK0431 | TK0434 | Hypothetical protein, conserved, containing DUF1246 and DUF1297 domains. | Thiazole biosynthetic enzyme Thi4; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.679 |
TK0431 | thiC | TK0431 | TK0433 | Hypothetical protein, conserved, containing DUF1246 and DUF1297 domains. | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.812 |
TK0435 | TK0431 | TK0435 | TK0431 | Phosphomethylpyrimidine kinase, fused to C-terminal uncharacterized domain. | Hypothetical protein, conserved, containing DUF1246 and DUF1297 domains. | 0.629 |
TK0435 | TK0436 | TK0435 | TK0436 | Phosphomethylpyrimidine kinase, fused to C-terminal uncharacterized domain. | ABC-type transporter, ATPase component, fused to acetyltransferase domain. | 0.731 |
TK0435 | TK2197 | TK0435 | TK2197 | Phosphomethylpyrimidine kinase, fused to C-terminal uncharacterized domain. | Predicted transcription regulator, fused to C-terminal uncharacterized domain. | 0.680 |
TK0435 | purC-2 | TK0435 | TK0432 | Phosphomethylpyrimidine kinase, fused to C-terminal uncharacterized domain. | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.701 |
TK0435 | purO | TK0435 | TK0430 | Phosphomethylpyrimidine kinase, fused to C-terminal uncharacterized domain. | Inosine 5'-monophosphate cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | 0.679 |
TK0435 | thi4 | TK0435 | TK0434 | Phosphomethylpyrimidine kinase, fused to C-terminal uncharacterized domain. | Thiazole biosynthetic enzyme Thi4; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.966 |
TK0435 | thiC | TK0435 | TK0433 | Phosphomethylpyrimidine kinase, fused to C-terminal uncharacterized domain. | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.999 |
TK0436 | TK0431 | TK0436 | TK0431 | ABC-type transporter, ATPase component, fused to acetyltransferase domain. | Hypothetical protein, conserved, containing DUF1246 and DUF1297 domains. | 0.517 |
TK0436 | TK0435 | TK0436 | TK0435 | ABC-type transporter, ATPase component, fused to acetyltransferase domain. | Phosphomethylpyrimidine kinase, fused to C-terminal uncharacterized domain. | 0.731 |
TK0436 | purC-2 | TK0436 | TK0432 | ABC-type transporter, ATPase component, fused to acetyltransferase domain. | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.521 |
TK0436 | purO | TK0436 | TK0430 | ABC-type transporter, ATPase component, fused to acetyltransferase domain. | Inosine 5'-monophosphate cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | 0.521 |
TK0436 | thi4 | TK0436 | TK0434 | ABC-type transporter, ATPase component, fused to acetyltransferase domain. | Thiazole biosynthetic enzyme Thi4; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.731 |