STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thsAThermosome subunit alpha; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity (548 aa)    
Predicted Functional Partners:
TK1082
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
 
 
 0.781
eif5a
Translation initiation factor 5A; Functions by promoting the formation of the first peptide bond
 
 
 0.748
rpoA2
DNA-directed RNA polymerase subunit A''; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
 
 
 0.742
TK0533
annotation not available
  
  
 0.736
tbp
TATA-box-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation
 
 
 
 0.731
psmA
Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation
 
 
 0.716
rpl4
50S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome
 
 
 0.714
rpl3
50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
 
 
 0.712
infB
Probable translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity)
 
 
 0.705
rpl10e
annotation not available
 
 
 0.704
Your Current Organism:
Thermococcus kodakarensis
NCBI taxonomy Id: 69014
Other names: Pyrococcus sp. (strain KOD1), Pyrococcus sp. KOD1, T. kodakarensis KOD1, Thermococcus kodakaraensis KOD1, Thermococcus kodakarensis, Thermococcus kodakarensis KOD1, Thermococcus kodakarensis str. KOD1, Thermococcus kodakarensis strain KOD1
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