STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEG50633.1KEGG: swi:Swit_5285 putative DNA topoisomerase I. (368 aa)    
Predicted Functional Partners:
AEG50629.1
DNA ligase D; KEGG: eli:ELI_04125 hypothetical protein; TIGRFAM: DNA ligase D; DNA polymerase LigD, ligase region; DNA ligase D, 3'-phosphoesterase domain; DNA polymerase LigD, polymerase domain; PFAM: ATP dependent DNA ligase, central; ATP dependent DNA ligase, C-terminal; DNA primase, small subunit.
 
 
 
 0.863
parE
DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
   
 
 0.774
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.774
rnhB
Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
    
 
 0.773
AEG49627.1
TIGRFAM: DNA helicase, ATP-dependent, RecQ type, bacterial; DNA helicase, ATP-dependent, RecQ type, N-terminal; PFAM: Helicase/RNase D C-terminal, HRDC domain; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; RQC domain; KEGG: sjp:SJA_C1-01670 ATP-dependent DNA helicase RecQ; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; Helicase/RNase D C-terminal, HRDC domain.
    
 
 0.773
AEG50632.1
KEGG: sjp:SJA_C2-05530 SDR-family protein; PFAM: Short-chain dehydrogenase/reductase SDR.
 
 
   0.761
ku
DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
    0.690
AEG50604.1
Cyclase/dehydrase; PFAM: Streptomyces cyclase/dehydrase; KEGG: sjp:SJA_C1-26500 putative cyclase/dehydrase.
 
     0.623
AEG51274.1
KEGG: swi:Swit_0129 hypothetical protein.
 
     0.566
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.546
Your Current Organism:
Sphingobium chlorophenolicum
NCBI taxonomy Id: 690566
Other names: FLAVOBACTERIUM SP. (STRAIN ATCC 39723), Flavobacterium sp. (ATCC 39723), Flavobacterium sp. ATCC 39723, S. chlorophenolicum L-1, Sphingobium chlorophenolicum ATCC 39723, Sphingobium chlorophenolicum L-1, Sphingobium chlorophenolicum str. L-1, Sphingobium chlorophenolicum strain L-1
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