node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CFX24268.1 | CFX46708.1 | 839 | 1274 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.713 |
CFX24268.1 | CFX85606.1 | 839 | 2044 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Aldolase-type TIM barrel; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.450 |
CFX24268.1 | CFX85982.1 | 839 | 2050 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Acetolactate synthase, small subunit. | 0.941 |
CFX24268.1 | CFX86020.1 | 839 | 2051 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Acetolactate synthase, large subunit, biosynthetic. | 0.671 |
CFX24268.1 | ilvC | 839 | 2049 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Acetohydroxy acid isomeroreductase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.785 |
CFX24268.1 | leuA | 839 | 2048 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 2-isopropylmalate synthase, bacterial-type; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.450 |
CFX24268.1 | leuB | 839 | 2045 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.677 |
CFX24268.1 | leuC | 839 | 2047 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.691 |
CFX24268.1 | leuD | 839 | 2046 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 3-isopropylmalate dehydratase, small subunit, subgroup; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.535 |
CFX46708.1 | CFX24268.1 | 1274 | 839 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.713 |
CFX46708.1 | CFX85606.1 | 1274 | 2044 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Aldolase-type TIM barrel; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.450 |
CFX46708.1 | CFX85982.1 | 1274 | 2050 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Acetolactate synthase, small subunit. | 0.941 |
CFX46708.1 | CFX86020.1 | 1274 | 2051 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Acetolactate synthase, large subunit, biosynthetic. | 0.671 |
CFX46708.1 | ilvC | 1274 | 2049 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Acetohydroxy acid isomeroreductase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.785 |
CFX46708.1 | leuA | 1274 | 2048 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 2-isopropylmalate synthase, bacterial-type; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.450 |
CFX46708.1 | leuB | 1274 | 2045 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.677 |
CFX46708.1 | leuC | 1274 | 2047 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.691 |
CFX46708.1 | leuD | 1274 | 2046 | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 3-isopropylmalate dehydratase, small subunit, subgroup; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.535 |
CFX85606.1 | CFX24268.1 | 2044 | 839 | Aldolase-type TIM barrel; Belongs to the alpha-IPM synthase/homocitrate synthase family. | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.450 |
CFX85606.1 | CFX46708.1 | 2044 | 1274 | Aldolase-type TIM barrel; Belongs to the alpha-IPM synthase/homocitrate synthase family. | D-3-phosphoglycerate dehydrogenase, type 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.450 |