node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Desaf_0030 | Desaf_3092 | Desaf_0030 | Desaf_3092 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: dsa:Desal_2300 methylenetetrahydrofolate reductase (NAD(P)H); PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | TIGRFAM: Glycine cleavage system T protein; KEGG: dde:Dde_1996 glycine cleavage system T protein; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel. | 0.938 |
Desaf_0030 | folD | Desaf_0030 | Desaf_0472 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: dsa:Desal_2300 methylenetetrahydrofolate reductase (NAD(P)H); PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.935 |
Desaf_0030 | glyA | Desaf_0030 | Desaf_2346 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: dsa:Desal_2300 methylenetetrahydrofolate reductase (NAD(P)H); PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.955 |
Desaf_1854 | Desaf_3092 | Desaf_1854 | Desaf_3092 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | TIGRFAM: Glycine cleavage system T protein; KEGG: dde:Dde_1996 glycine cleavage system T protein; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel. | 0.937 |
Desaf_1854 | fmt | Desaf_1854 | Desaf_1520 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.546 |
Desaf_1854 | folD | Desaf_1854 | Desaf_0472 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.968 |
Desaf_1854 | glyA | Desaf_1854 | Desaf_2346 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.980 |
Desaf_1854 | purD | Desaf_1854 | Desaf_0259 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: dsa:Desal_3434 phosphoribosylamine/glycine ligase; Belongs to the GARS family. | 0.962 |
Desaf_1854 | purN | Desaf_1854 | Desaf_1010 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.998 |
Desaf_2751 | folD | Desaf_2751 | Desaf_0472 | KEGG: dvu:DVU0366 5-formyltetrahydrofolate cyclo-ligase family protein; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.935 |
Desaf_2751 | glyA | Desaf_2751 | Desaf_2346 | KEGG: dvu:DVU0366 5-formyltetrahydrofolate cyclo-ligase family protein; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.437 |
Desaf_2751 | purN | Desaf_2751 | Desaf_1010 | KEGG: dvu:DVU0366 5-formyltetrahydrofolate cyclo-ligase family protein; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.919 |
Desaf_3092 | Desaf_0030 | Desaf_3092 | Desaf_0030 | TIGRFAM: Glycine cleavage system T protein; KEGG: dde:Dde_1996 glycine cleavage system T protein; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: dsa:Desal_2300 methylenetetrahydrofolate reductase (NAD(P)H); PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.938 |
Desaf_3092 | Desaf_1854 | Desaf_3092 | Desaf_1854 | TIGRFAM: Glycine cleavage system T protein; KEGG: dde:Dde_1996 glycine cleavage system T protein; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel. | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | 0.937 |
Desaf_3092 | fmt | Desaf_3092 | Desaf_1520 | TIGRFAM: Glycine cleavage system T protein; KEGG: dde:Dde_1996 glycine cleavage system T protein; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.930 |
Desaf_3092 | folD | Desaf_3092 | Desaf_0472 | TIGRFAM: Glycine cleavage system T protein; KEGG: dde:Dde_1996 glycine cleavage system T protein; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel. | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.970 |
Desaf_3092 | glyA | Desaf_3092 | Desaf_2346 | TIGRFAM: Glycine cleavage system T protein; KEGG: dde:Dde_1996 glycine cleavage system T protein; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
Desaf_3092 | purD | Desaf_3092 | Desaf_0259 | TIGRFAM: Glycine cleavage system T protein; KEGG: dde:Dde_1996 glycine cleavage system T protein; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel. | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: dsa:Desal_3434 phosphoribosylamine/glycine ligase; Belongs to the GARS family. | 0.508 |
Desaf_3092 | purN | Desaf_3092 | Desaf_1010 | TIGRFAM: Glycine cleavage system T protein; KEGG: dde:Dde_1996 glycine cleavage system T protein; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.931 |
Desaf_3092 | purU | Desaf_3092 | Desaf_3081 | TIGRFAM: Glycine cleavage system T protein; KEGG: dde:Dde_1996 glycine cleavage system T protein; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.929 |