Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
prpECatalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (625 aa)    
Predicted Functional Partners:
ANQ21707.1
2-methylcitrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.
  
 0.975
ANQ22099.1
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
    
 0.926
ANQ24320.1
acetate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 
0.922
acsA
acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
  
 
0.911
ANQ21869.1
Methylmalonate-semialdehyde dehydrogenase (acylating); Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.910
ANQ23288.1
Methylmalonate-semialdehyde dehydrogenase (acylating); Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.910
ANQ23982.1
Methylmalonate-semialdehyde dehydrogenase (acylating); Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.910
ANQ24914.1
Methylmalonate-semialdehyde dehydrogenase (acylating); Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.910
ANQ20161.1
Quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.909
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
     
 0.909
Your Current Organism:
Vibrio natriegens
NCBI taxonomy Id: 691
Other names: ATCC 14048, Beneckea natriegens, CAIM 12, CCUG 16371, CCUG 4980 A, CIP 103193, DSM 759, IFO 15636, LMG 10935, LMG:10935, NBRC 15636, NCCB 73019, NCMB 857, NCMB:857, NCTC 11319, Pseudomonas natriegens, V. natriegens
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