H696_00275 protein (Fonticula alba) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

Experiments

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[Homology]

Score

H696_00275

Uncharacterized protein. (189 aa)

Predicted Functional Partners:

H696_00254

0.652

H696_02078

0.645

H696_00286

0.510

H696_00069

0.450

H696_01492

0.417

H696_03882

0.416

Your Current Organism:

Fonticula alba

NCBI taxonomy Id: 691883
Other names: F. alba

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H696_00069	H696_00275	A0A058ZEX7	A0A058ZFG7	SB domain-containing protein.	Uncharacterized protein.	0.450
H696_00069	H696_01492	A0A058ZEX7	A0A058ZCH7	SB domain-containing protein.	BRO1 domain-containing protein.	0.711
H696_00069	H696_02078	A0A058ZEX7	A0A058ZCG3	SB domain-containing protein.	BRO1 domain-containing protein.	0.934
H696_00254	H696_00275	A0A058ZE79	A0A058ZFG7	Uncharacterized protein.	Uncharacterized protein.	0.652
H696_00275	H696_00069	A0A058ZFG7	A0A058ZEX7	Uncharacterized protein.	SB domain-containing protein.	0.450
H696_00275	H696_00254	A0A058ZFG7	A0A058ZE79	Uncharacterized protein.	Uncharacterized protein.	0.652
H696_00275	H696_00286	A0A058ZFG7	A0A058ZGT9	Uncharacterized protein.	G domain-containing protein.	0.510
H696_00275	H696_01492	A0A058ZFG7	A0A058ZCH7	Uncharacterized protein.	BRO1 domain-containing protein.	0.417
H696_00275	H696_02078	A0A058ZFG7	A0A058ZCG3	Uncharacterized protein.	BRO1 domain-containing protein.	0.645
H696_00275	H696_03882	A0A058ZFG7	A0A058Z6D0	Uncharacterized protein.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	0.416
H696_00286	H696_00275	A0A058ZGT9	A0A058ZFG7	G domain-containing protein.	Uncharacterized protein.	0.510
H696_01492	H696_00069	A0A058ZCH7	A0A058ZEX7	BRO1 domain-containing protein.	SB domain-containing protein.	0.711
H696_01492	H696_00275	A0A058ZCH7	A0A058ZFG7	BRO1 domain-containing protein.	Uncharacterized protein.	0.417
H696_02078	H696_00069	A0A058ZCG3	A0A058ZEX7	BRO1 domain-containing protein.	SB domain-containing protein.	0.934
H696_02078	H696_00275	A0A058ZCG3	A0A058ZFG7	BRO1 domain-containing protein.	Uncharacterized protein.	0.645
H696_03882	H696_00275	A0A058Z6D0	A0A058ZFG7	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	Uncharacterized protein.	0.416

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.785

expected number of edges:

10

PPI enrichment p-value:

1.38e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006810

Transport

11 of 296

0.87

0.94

3.41e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022857

Transmembrane transporter activity

10 of 224

0.95

1.05

8.03e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

7 of 294

0.68

0.48

0.0090

GO:0016020

Membrane

11 of 638

0.54

0.46

0.00014

GO:0016021

Integral component of membrane

8 of 435

0.57

0.41

0.0090

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3162

Palmitate, and RND efflux pump, membrane fusion protein

9 of 13

2.14

6.11

1.80e-15

CL:3160

Mixed, incl. Outer membrane efflux protein, and RND efflux pump, membrane fusion protein

10 of 22

1.96

5.53

4.22e-16

CL:3164

Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains, and RND efflux pump, membrane fusion protein, barrel-sandwich domain

5 of 7

2.16

3.48

5.43e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01501

beta-Lactam resistance

5 of 46

1.34

1.3

0.00025

map01503

Cationic antimicrobial peptide (CAMP) resistance

4 of 37

1.34

1.09

0.0017

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990281

Efflux pump complex

5 of 5

2.3

3.6

6.24e-08

GOCC:0098567

Periplasmic side of plasma membrane

5 of 8

2.1

3.22

1.58e-07

GOCC:0005886

Plasma membrane

10 of 277

0.86

0.91

6.69e-07

GOCC:0016020

Membrane

11 of 418

0.72

0.71

6.69e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0175

Coiled coil

6 of 177

0.83

0.6

0.0061

KW-0812

Transmembrane

9 of 415

0.64

0.49

0.0023

KW-1133

Transmembrane helix

8 of 397

0.61

0.44

0.0061

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13533

Biotin-lipoyl like

4 of 5

2.21

2.47

1.36e-05

PF13437

HlyD family secretion protein

3 of 4

2.18

1.71

0.00052

PF03176

MMPL family

3 of 5

2.08

1.67

0.00056

PF16576

Barrel-sandwich domain of CusB or HlyD membrane-fusion

2 of 2

2.3

1.06

0.0111

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027463

Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains

4 of 4

2.3

2.43

2.01e-05

IPR006143

RND efflux pump, membrane fusion protein

4 of 4

2.3

2.43

2.01e-05

IPR001036

Acriflavin resistance protein

4 of 5

2.21

2.39

2.01e-05

IPR032317

RND efflux pump, membrane fusion protein, barrel-sandwich domain

3 of 3

2.3

1.8

0.00040

IPR039562

Membrane fusion protein, biotin-lipoyl like domain

2 of 3

2.13

0.76

0.0393

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