Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TBC1D8TBC1 domain family member 8. (1106 aa)    
Predicted Functional Partners:
G3PKG3_GASAC
Cyclin G associated kinase.
   
 
  0.694
MZT1
Mitotic spindle organizing protein 1.
   
  
 0.680
G3NB61_GASAC
Cell division cycle 16 homolog (S. cerevisiae).
      
 0.671
G3N7T4_GASAC
Bystin-like.
    
   0.653
G3PE37_GASAC
GTPase activating protein and VPS9 domains 1.
   
 
 0.649
G3PXA6_GASAC
Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]
   
 
  0.628
TMEM179
Transmembrane protein 179.
      
 0.625
G3P9S0_GASAC
Protein YIPF.
   
 
  0.616
G3NYN5_GASAC
Adaptor related protein complex 5 subunit mu 1; Belongs to the adaptor complexes medium subunit family.
     
 0.611
G3NRF7_GASAC
Adaptor related protein complex 4 subunit epsilon 1.
     
  0.600
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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