G3N7N0_GASAC protein (Gasterosteus aculeatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

G3N7N0_GASAC

ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (639 aa)

Predicted Functional Partners:

G3NE68_GASAC

0.910

G3PBI6_GASAC

0.910

FEN1

0.906

G3PT40_GASAC

0.906

G3NS32_GASAC

0.879

G3NSY0_GASAC

0.875

G3PUG9_GASAC

0.804

SMARCAL1

0.792

APLF

0.790

G3PIT7_GASAC

0.788

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLF	G3N7N0_GASAC	ENSGACP00000026005	ENSGACP00000001313	Aprataxin and PNKP like factor.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.790
APLF	G3NS32_GASAC	ENSGACP00000026005	ENSGACP00000008149	Aprataxin and PNKP like factor.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.985
APLF	G3PBI6_GASAC	ENSGACP00000026005	ENSGACP00000014960	Aprataxin and PNKP like factor.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.989
FEN1	G3N7N0_GASAC	ENSGACP00000002941	ENSGACP00000001313	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.906
FEN1	G3NE68_GASAC	ENSGACP00000002941	ENSGACP00000003619	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.957
FEN1	G3NS32_GASAC	ENSGACP00000002941	ENSGACP00000008149	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.734
FEN1	G3NSY0_GASAC	ENSGACP00000002941	ENSGACP00000008448	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.745
FEN1	G3PBI6_GASAC	ENSGACP00000002941	ENSGACP00000014960	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.858
FEN1	G3PUG9_GASAC	ENSGACP00000002941	ENSGACP00000021256	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication helicase/nuclease 2.	0.963
FEN1	SMARCAL1	ENSGACP00000002941	ENSGACP00000008040	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.628
G3N7N0_GASAC	APLF	ENSGACP00000001313	ENSGACP00000026005	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Aprataxin and PNKP like factor.	0.790
G3N7N0_GASAC	FEN1	ENSGACP00000001313	ENSGACP00000002941	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.906
G3N7N0_GASAC	G3NE68_GASAC	ENSGACP00000001313	ENSGACP00000003619	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.910
G3N7N0_GASAC	G3NS32_GASAC	ENSGACP00000001313	ENSGACP00000008149	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.879
G3N7N0_GASAC	G3NSY0_GASAC	ENSGACP00000001313	ENSGACP00000008448	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Uncharacterized protein.	0.875
G3N7N0_GASAC	G3PBI6_GASAC	ENSGACP00000001313	ENSGACP00000014960	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.910
G3N7N0_GASAC	G3PIT7_GASAC	ENSGACP00000001313	ENSGACP00000017516	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Chloride channel, nucleotide-sensitive, 1A.	0.788
G3N7N0_GASAC	G3PT40_GASAC	ENSGACP00000001313	ENSGACP00000020776	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Zgc:110269.	0.906
G3N7N0_GASAC	G3PUG9_GASAC	ENSGACP00000001313	ENSGACP00000021256	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	DNA replication helicase/nuclease 2.	0.804
G3N7N0_GASAC	SMARCAL1	ENSGACP00000001313	ENSGACP00000008040	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.792