STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
G3N7S4_GASACCyclin-dependent kinase inhibitor 1A. (191 aa)    
Predicted Functional Partners:
G3Q3M3_GASAC
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase.
    
 0.979
G3N5X5_GASAC
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.967
G3PG64_GASAC
Cyclin E1; Belongs to the cyclin family.
   
 0.965
G3Q6V4_GASAC
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.964
CCNE2
Cyclin E2; Belongs to the cyclin family.
   
 0.962
G3Q0P6_GASAC
Cyclin E2; Belongs to the cyclin family.
   
 0.962
G3PM83_GASAC
Cyclin D1; Belongs to the cyclin family.
   
 0.960
G3N643_GASAC
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.957
G3PWM1_GASAC
Cyclin A2; Belongs to the cyclin family.
    
 0.956
G3QBB4_GASAC
Cyclin A1; Belongs to the cyclin family.
    
 0.956
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.